Department of Molecular Biology
Simches Research Center
Boston, MA 02114
About Sharmistha Kundu
My research goals include understanding how PRC1-mediated chromatin interactions change as pluripotent cells make specific cell-fate choices. To address this question, I am using neural differentiation of embryonic stem cells as a model. I completed my M.S. at the Indian Institute of Science, where I worked to develop a new in vitro system for studying transcription in a high DNA density environment. For my Ph.D. I worked with Craig Peterson at UMass Medical School, studying the role of chromatin remodeling during transcriptional choice in budding yeast. Prior to joining the Kingston lab, I was a JDRF fellow at Stanford University studying transcriptional regulation of pancreatic beta-cell formation and their proliferation during mouse embryonic development.Publications
- Deaton AM, Mieczkowski J, Tolstorukov MY, Kundu S, Sadreyev RI, Jansen LE, Kingston RE. Enhancer regions show high histone H3.3 turnover that changes during differentiation. Elife 2016 Jun 15; 5
- Mieczkowski J, Cook A, Bowman SK, Mueller B, Alver BH, Kundu S, Deaton AM, Urban JA, Larschan E, Park PJ, Kingston RE, Tolstorukov MY. MNase titration reveals differences between nucleosome occupancy and chromatin accessibility. Nat Commun 2016 May 06; 7:11485.
- Kundu S, Peterson CL. Dominant role for signal transduction in the transcriptional memory of yeast GAL genes. Mol. Cell. Biol. 2010 May; 30(10):2330-40.
- Kundu S, Peterson CL. Role of chromatin states in transcriptional memory. Biochim. Biophys. Acta 2009 Jun; 1790(6):445-55.
- Kundu S, Horn PJ, Peterson CL. SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster. Genes Dev. 2007 Apr 15; 21(8):997-1004.
- Ghosh D, Faure N, Kundu S, Rondalez F, Chatterji D. Hybridization and Immobilization of Long ds-DNAs on Polystyrene Microspheres. Langmuir. 2003; 19(14):5830-5837.