Denis Titov

Mootha Lab

Research Fellow

Department of Molecular Biology
Simches Research Center
Boston, MA 02114


  1. Titov DV, Cracan V, Goodman RP, Peng J, Grabarek Z, Mootha VK. Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science 2016 Apr 8; 352(6282):231-5.

  2. Lewis-Smith D, Kamer KJ, Griffin H, Childs AM, Pysden K, Titov D, Duff J, Pyle A, Taylor RW, Yu-Wai-Man P, Ramesh V, Horvath R, Mootha VK, Chinnery PF. Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood. Neurol Genet 2016 Apr; 2(2):e59.

  3. 2015
  4. He QL, Titov DV, Li J, Tan M, Ye Z, Zhao Y, Romo D, Liu JO. Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide. Angew. Chem. Int. Ed. Engl. 2015 Feb 2; 54(6):1859-63.

  5. 2012
  6. Titov DV, Liu JO. Identification and validation of protein targets of bioactive small molecules. Bioorg. Med. Chem. 2012 Mar 15; 20(6):1902-9.

  7. 2011
  8. Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, Goodrich JA, Liu JO. XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat. Chem. Biol. 2011 Mar; 7(3):182-8.

  9. Liu JO, Titov DV, Dang Y, He Q. Regulator of Ras depalmitoylation and retrograde trafficking: a new hat for FKBP. Mol. Cell 2011 Jan 21; 41(2):131-3.

  10. 2006
  11. Ni Q, Titov DV, Zhang J. Analyzing protein kinase dynamics in living cells with FRET reporters. Methods 2006 Nov; 40(3):279-86.

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