Christine Kocks

Ausubel Lab


Research Fellow

Department of Molecular Biology
Simches Research Center
Boston, MA 02114


Email

Publications
    2011
  1. Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, Ausubel FM, Ferrandon D. Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model. Proc. Natl. Acad. Sci. U.S.A. 2011 Oct 18; 108(42):17378-83.

  2. Chung YS, Kocks C. Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater. J. Biol. Chem. 2011 Jul 29; 286(30):26524-32.

  3. Ulvila J, Vanha-aho LM, Kleino A, Vähä-Mäkilä M, Vuoksio M, Eskelinen S, Hultmark D, Kocks C, Hallman M, Parikka M, Rämet M. Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance. J. Leukoc. Biol. 2011 May; 89(5):649-59.

  4. Nehme NT, Quintin J, Cho JH, Lee J, Lafarge MC, Kocks C, Ferrandon D. Relative roles of the cellular and humoral responses in the Drosophila host defense against three gram-positive bacterial infections. PLoS ONE 2011; 6(3):e14743.

  5. 2007
  6. Diakonova M, Helfer E, Seveau S, Swanson JA, Kocks C, Rui L, Carlier MF, Carter-Su C. Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion. Infect. Immun. 2007 Jul; 75(7):3581-93.

  7. Stuart LM, Boulais J, Charriere GM, Hennessy EJ, Brunet S, Jutras I, Goyette G, Rondeau C, Letarte S, Huang H, Ye P, Morales F, Kocks C, Bader JS, Desjardins M, Ezekowitz RA. A systems biology analysis of the Drosophila phagosome. Nature 2007 Jan 4; 445(7123):95-101.

  8. 2006
  9. Ulvila J, Parikka M, Kleino A, Sormunen R, Ezekowitz RA, Kocks C, Rämet M. Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J. Biol. Chem. 2006 May 19; 281(20):14370-5.

  10. 2005
  11. Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Rämet M, Ezekowitz RA. Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell 2005 Oct 21; 123(2):335-46.

  12. 2003
  13. Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Mol. Cell Proteomics 2003 Nov; 2(11):1188-97.

  14. Samarin S, Romero S, Kocks C, Didry D, Pantaloni D, Carlier MF. How VASP enhances actin-based motility. J. Cell Biol. 2003 Oct 13; 163(1):131-42.

  15. 2001
  16. Boujemaa-Paterski R, Gouin E, Hansen G, Samarin S, Le Clainche C, Didry D, Dehoux P, Cossart P, Kocks C, Carlier MF, Pantaloni D. Listeria protein ActA mimics WASp family proteins: it activates filament barbed end branching by Arp2/3 complex. Biochemistry 2001 Sep 25; 40(38):11390-404.

  17. Herd M, Kocks C. Gene fragments distinguishing an epidemic-associated strain from a virulent prototype strain of Listeria monocytogenes belong to a distinct functional subset of genes and partially cross-hybridize with other Listeria species. Infect. Immun. 2001 Jun; 69(6):3972-9.

  18. 1999
  19. Cicchetti G, Maurer P, Wagener P, Kocks C. Actin and phosphoinositide binding by the ActA protein of the bacterial pathogen Listeria monocytogenes. J. Biol. Chem. 1999 Nov 19; 274(47):33616-26.

  20. 1997
  21. Schwenk F, Sauer B, Kukoc N, Hoess R, Müller W, Kocks C, Kühn R, Rajewsky K. Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains. J. Immunol. Methods 1997 Sep 24; 207(2):203-12.

  22. 1995
  23. Kocks C, Marchand JB, Gouin E, d'Hauteville H, Sansonetti PJ, Carlier MF, Cossart P. The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli respectively. Mol. Microbiol. 1995 Nov; 18(3):413-23.

  24. Gouin E, Dehoux P, Mengaud J, Kocks C, Cossart P. iactA of Listeria ivanovii, although distantly related to Listeria monocytogenes actA, restores actin tail formation in an L. monocytogenes actA mutant. Infect. Immun. 1995 Jul; 63(7):2729-37.

  25. Friederich E, Gouin E, Hellio R, Kocks C, Cossart P, Louvard D. Targeting of Listeria monocytogenes ActA protein to the plasma membrane as a tool to dissect both actin-based cell morphogenesis and ActA function. EMBO J. 1995 Jun 15; 14(12):2731-44.

  26. 1994
  27. Cossart P, Kocks C. The actin-based motility of the facultative intracellular pathogen Listeria monocytogenes. Mol. Microbiol. 1994 Aug; 13(3):395-402.

  28. Kocks C. Intracellular motility. Profilin puts pathogens on the actin drive. Curr. Biol. 1994 May 1; 4(5):465-8.

  29. Sheehan B, Kocks C, Dramsi S, Gouin E, Klarsfeld AD, Mengaud J, Cossart P. Molecular and genetic determinants of the Listeria monocytogenes infectious process. Curr. Top. Microbiol. Immunol. 1994; 192:187-216.

  30. 1993
  31. Dramsi S, Kocks C, Forestier C, Cossart P. Internalin-mediated invasion of epithelial cells by Listeria monocytogenes is regulated by the bacterial growth state, temperature and the pleiotropic activator prfA. Mol. Microbiol. 1993 Sep; 9(5):931-41.

  32. Falzano L, Fiorentini C, Donelli G, Michel E, Kocks C, Cossart P, Cabanié L, Oswald E, Boquet P. Induction of phagocytic behaviour in human epithelial cells by Escherichia coli cytotoxic necrotizing factor type 1. Mol. Microbiol. 1993 Sep; 9(6):1247-54.

  33. Kocks C, Cossart P. Directional actin assembly by Listeria monocytogenes at the site of polar surface expression of the actA gene product involving the actin-bundling protein plastin (fimbrin). Infect Agents Dis 1993 Aug; 2(4):207-9.

  34. Kocks C, Hellio R, Gounon P, Ohayon H, Cossart P. Polarized distribution of Listeria monocytogenes surface protein ActA at the site of directional actin assembly. J. Cell. Sci. 1993 Jul; 105 ( Pt 3):699-710.

  35. Aullo P, Giry M, Olsnes S, Popoff MR, Kocks C, Boquet P. A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly. EMBO J. 1993 Mar; 12(3):921-31.

  36. 1992
  37. Kocks C, Gouin E, Tabouret M, Berche P, Ohayon H, Cossart P. L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein. Cell 1992 Feb 7; 68(3):521-31.

  38. Vazquez-Boland JA, Kocks C, Dramsi S, Ohayon H, Geoffroy C, Mengaud J, Cossart P. Nucleotide sequence of the lecithinase operon of Listeria monocytogenes and possible role of lecithinase in cell-to-cell spread. Infect. Immun. 1992 Jan; 60(1):219-30.

  39. 1989
  40. Kocks C, Rajewsky K. Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways. Annu. Rev. Immunol. 1989; 7:537-59.

  41. 1988
  42. Kocks C, Rajewsky K. Stepwise intraclonal maturation of antibody affinity through somatic hypermutation. Proc. Natl. Acad. Sci. U.S.A. 1988 Nov; 85(21):8206-10.

  43. 1987
  44. Allen D, Cumano A, Dildrop R, Kocks C, Rajewsky K, Roes J, Sablitzky F, Siekevitz M. Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development. Immunol. Rev. 1987 Apr; 96:5-22.

  45. Siekevitz M, Kocks C, Rajewsky K, Dildrop R. Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses. Cell 1987 Mar 13; 48(5):757-70.

  46. 1985
  47. Gelderblom HR, Kocks C, L'Age-Stehr J, Reupke H. Comparative immunoelectron microscopy with monoclonal antibodies on yellow fever virus-infected cells: pre-embedding labelling versus immunocryoultramicrotomy. J. Virol. Methods 1985 Mar; 10(3):225-39.

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