Enver Cagri Izgu

Szostak Lab


Research Fellow

Department of Molecular Biology
Simches Research Center
Boston, MA 02114


Email

About Enver Cagri Izgu

I graduated from the University of Minnesota with a Ph.D. in organic chemistry. My postdoctoral research focuses on the chemical approaches to genetic information transfer and protocell construction. More specifically, I am working on i) the thermodynamic binding interactions between nucleotides and nucleic acid duplexes, ii) the nonenzymatic replication of informational polymers, and iii) the cooperative existence of amino acids, short peptides, and fatty acid vesicles.

Publications
    2017
  1. Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW. Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. J. Am. Chem. Soc. 2017 Jan 24.

  2. Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW. Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes. J. Am. Chem. Soc. 2017 Jan 18; 139(2):571-574.

  3. 2016
  4. Izgu EC, Björkbom A, Kamat NP, Lelyveld VS, Zhang W, Jia TZ, Szostak JW. N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes. J. Am. Chem. Soc. 2016 Dec 28; 138(51):16669-16676.

  5. Izgu EC, Oh SS, Szostak JW. Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. Chem. Commun. (Camb.) 2016 Feb 9.

  6. 2015
  7. Izgu EC, Fahrenbach AC, Zhang N, Li L, Larsen AT, Blain JC, Szostak JW. Uncovering the thermodynamics of monomer binding for RNA replication. J. Am. Chem. Soc. 2015 May 20; 137(19):6373-82.

  8. 2013
  9. Izgu EC, Hoye TR. Total synthesis of (±)-leuconolam: intramolecular allylic silane addition to a maleimide carbonyl group. Chem Sci 2013 Feb; 4(5):2262-2266.

  10. 2012
  11. Izgu EC, Hoye TR. o-(Trialkylstannyl)anilines and Their Utility in Stille Cross-Coupling: Direct Introduction of the 2-Aminophenyl Substituent. Tetrahedron Lett. 2012 Sep 12; 53(37):4938-4941.

  12. 2011
  13. Izgu EC, Burns AC, Hoye TR. Access to functionalized steroid side chains via modified Julia olefination. Org. Lett. 2011 Feb 18; 13(4):703-5.

  14. 2010
  15. Hoye TR, Erickson SE, Erickson-Birkedahl SL, Hale CR, Izgu EC, Mayer MJ, Notz PK, Renner MK. Long-range shielding effects in the (1)H NMR spectra of Mosher-like ester derivatives. Org. Lett. 2010 Apr 16; 12(8):1768-71.

  16. 2007
  17. Bulut A, Aslan A, Izgu EC, Dogan O. Catalytic Enantioselective Addition of Diethylzinc to Aldehydes Using Aziridine Based Chiral Ligands. .

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