Bruno Di Stefano

Hochedlinger Lab

Research Fellow


  1. Di Stefano B, Hochedlinger K. Cell reprogramming: Brain versus brawn. Nature 2016 Jun 16; 534(7607):332-3.

  2. Sardina JL, Di Stefano B, Graf T. How does C/EBPα speed up cell reprogramming? Cell Cycle 2016 Jun 7.

  3. Di Stefano B, Collombet S, Jakobsen JS, Wierer M, Sardina JL, Lackner A, Stadhouders R, Segura-Morales C, Francesconi M, Limone F, Mann M, Porse B, Thieffry D, Graf T. C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4. Nat. Cell Biol. 2016 Mar 14.

  4. Krijger PH, Di Stefano B, de Wit E, Limone F, van Oevelen C, de Laat W, Graf T. Cell-of-Origin-Specific 3D Genome Structure Acquired during Somatic Cell Reprogramming. Cell Stem Cell 2016 Mar 8.

  5. Di Stefano B, Graf T. Very Rapid and Efficient Generation of Induced Pluripotent Stem Cells from Mouse Pre-B Cells. Methods Mol. Biol. 2016; 1357:45-56.

  6. 2015
  7. Bueno C, Sardina JL, Di Stefano B, Romero-Moya D, Ariza L, Balanzategui A, Herreros A, Fraga MF, Granada I, Quintana-Bustamante O, Segovia JC, Nishimura K, Ohtaka M, Nakanishi M, Graf T, Menendez P. Reprogramming human B cells into induced pluripotent stem cells and its enhancement by C/EBP?. Leukemia 2015 Oct 26.

  8. 2014
  9. Di Stefano B, Graf T. Hi-TEC reprogramming for organ regeneration. Nat. Cell Biol. 2014 Sep; 16(9):824-5.

  10. Di Stefano B, Sardina JL, van Oevelen C, Collombet S, Kallin EM, Vicent GP, Lu J, Thieffry D, Beato M, Graf T. C/EBP? poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature 2014 Feb 13; 506(7487):235-9.

  11. Aloia L, Di Stefano B, Sessa A, Morey L, Santanach A, Gutierrez A, Cozzuto L, Benitah SA, Graf T, Broccoli V, Di Croce L. Zrf1 is required to establish and maintain neural progenitor identity. Genes Dev. 2014 Jan 15; 28(2):182-97.

  12. Di Stefano B, Collombet S, Graf T. Time-resolved gene expression profiling during reprogramming of C/EBP?-pulsed B cells into iPS cells. Sci Data 2014; 1:140008.

  13. 2013
  14. Aloia L, Di Stefano B, Di Croce L. Polycomb complexes in stem cells and embryonic development. Development 2013 Jun; 140(12):2525-34.

  15. 2011
  16. Di Stefano B, Maffioletti SM, Gentner B, Ungaro F, Schira G, Naldini L, Broccoli V. A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells. Stem Cells 2011 Nov; 29(11):1684-95.

  17. Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, Di Stefano B, Mantegazza R, Broccoli V, Dityatev A, Sala C. Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 2011 Oct 7; 286(40):34839-50.

  18. Lombardo A, Cesana D, Genovese P, Di Stefano B, Provasi E, Colombo DF, Neri M, Magnani Z, Cantore A, Lo Riso P, Damo M, Pello OM, Holmes MC, Gregory PD, Gritti A, Broccoli V, Bonini C, Naldini L. Site-specific integration and tailoring of cassette design for sustainable gene transfer. Nat. Methods 2011; 8(10):861-9.

  19. 2010
  20. Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V. An ES-like pluripotent state in FGF-dependent murine iPS cells. PLoS ONE 2010; 5(12):e16092.

  21. 2009
  22. Di Stefano B, Prigione A, Broccoli V. Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4. Stem Cells Dev. 2009 Jun; 18(5):707-16.

  23. 2008
  24. Fiorio E, Mercanti A, Terrasi M, Micciolo R, Remo A, Auriemma A, Molino A, Parolin V, Di Stefano B, Bonetti F, Giordano A, Cetto GL, Surmacz E. Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis. BMC Cancer 2008; 8:305.

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