Department of Genetics and Genome Sciences, UConn Health
About Stefan Pinter
I obtained my PhD in Molecular Biology from Princeton University where I studied helicase function in nuclear and mitochondrial DNA replication and repair. In Dr. Jeannie Lee's lab, I am primarily interested in using genomic tools to examine how sequence context directs trans-acting factors in specifying chromatin states over large chromosomal domains. What role do non-coding RNAs play in this process and can we link specific factors to regulation of somatic or germline development?Publications
- Pinter SF, Sadreyev RI, Yildirim E, Jeon Y, Ohsumi TK, Borowsky M, Lee JT. Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations. Genome Res. 2012 Oct; 22(10):1864-76.
- Yildirim E, Sadreyev RI, Pinter SF, Lee JT. X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. Nat. Struct. Mol. Biol. 2012 Jan; 19(1):56-61.
- Spencer RJ, del Rosario BC, Pinter SF, Lessing D, Sadreyev RI, Lee JT. A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation. Genetics 2011 Oct; 189(2):441-54.
- Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature 2009 Jul 2; 460(7251):128-32.
- Pinter SF, Aubert SD, Zakian VA. The Schizosaccharomyces pombe Pfh1p DNA helicase is essential for the maintenance of nuclear and mitochondrial DNA. Mol. Cell. Biol. 2008 Nov; 28(21):6594-608.