Kavitha Sarma

Lee Lab


Assitant Professor

The Wistar Institute


Email

About Kavitha Sarma

I received my PhD in Biochemistry from the University of Medicine and Dentistry of New Jersey. During my graduate studies in Dr. Danny Reinberg's lab, I worked on the identification and characterization of histone methyltransferases and their associated proteins. I joined the Lee Lab to continue my studies in the field of chromatin biology. My current interests include mechanisms of Xist RNA silencing and spreading.

Publications
    2012
  1. Jeon Y, Sarma K, Lee JT. New and Xisting regulatory mechanisms of X chromosome inactivation. Curr. Opin. Genet. Dev. 2012 Apr; 22(2):62-71.

  2. 2010
  3. Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Borowsky M, Lee JT. Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol. Cell 2010 Dec 22; 40(6):939-53.

  4. Sarma K, Levasseur P, Aristarkhov A, Lee JT. Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome. Proc. Natl. Acad. Sci. U.S.A. 2010 Dec 21; 107(51):22196-201.

  5. 2008
  6. Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol. Cell 2008 Nov 21; 32(4):503-18.

  7. Sarma K, Margueron R, Ivanov A, Pirrotta V, Reinberg D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol. Cell. Biol. 2008 Apr; 28(8):2718-31.

  8. 2005
  9. Sarma K, Reinberg D. Histone variants meet their match. Nat. Rev. Mol. Cell Biol. 2005 Feb; 6(2):139-49.

  10. 2004
  11. Rougeulle C, Chaumeil J, Sarma K, Allis CD, Reinberg D, Avner P, Heard E. Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol. Cell. Biol. 2004 Jun; 24(12):5475-84.

  12. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1; 18(11):1251-62.

  13. Sarma K, Nishioka K, Reinberg D. Tips in analyzing antibodies directed against specific histone tail modifications. Meth. Enzymol. 2004; 376:255-69.

  14. 2002
  15. Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol. Cell 2002 Jun; 9(6):1201-13.

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