Brian Del Rosario
Department of Molecular Biology
Simches Research Center
Boston, MA 02114
About Brian Del Rosario
I received my bachelor's degree in molecular and cell biology from Cornell University. Then I completed my PhD in microbiology at the University of Virginia. At UVA, I was mentored by Dr. Lucy Pemberton and studied the molecular mechanisms of the histone chaperone Nap1. My current research interests include determining how chromatin associated factors function as molecular switches to regulate gene dosage.Publications
- Xue YM, Kowalska AK, Grabowska K, Przybyt K, Cichewicz MA, Del Rosario BC, Pemberton LF. Histone Chaperones Nap1 and Vps75 Regulate Histone Acetylation during Transcription Elongation. Mol. Cell. Biol. 2013 Apr; 33(8):1645-56.
- Erwin JA, Del Rosario B, Payer B, Lee JT. An ex Vivo Model for Imprinting: Mutually Exclusive Binding of Cdx2 and Oct4 as a Switch for Imprinted and Random X-Inactivation. Genetics 2012 Nov; 192(3):857-68.
- Spencer RJ, del Rosario BC, Pinter SF, Lessing D, Sadreyev RI, Lee JT. A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation. Genetics 2011 Oct; 189(2):441-54.
- Del Rosario BC, Pemberton LF. Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis. Mol. Cell. Biol. 2008 Apr; 28(7):2113-24.
- Mosammaparast N, Del Rosario BC, Pemberton LF. Modulation of histone deposition by the karyopherin kap114. Mol. Cell. Biol. 2005 Mar; 25(5):1764-78.
- Cheshenko N, Del Rosario B, Woda C, Marcellino D, Satlin LM, Herold BC. Herpes simplex virus triggers activation of calcium-signaling pathways. J. Cell Biol. 2003 Oct 27; 163(2):283-93.