Assistant in Molecular Biology
Department of Molecular Biology
Simches Research Center
Boston, MA 02114
About Sylvia Fischer
Interests: Mechanism and function of small RNA-mediated processes in C. elegans. I am interested in how small RNAs silence their targets. Currently, using both genetic mutants and a genome-wide RNAi screen, I am analyzing the negative regulation of RNAi in C. elegans. Through these analyses I hope to gain more insight into the RNAi pathway and into the function of small RNAs in C. elegans.Publications
- Fischer SE. Small RNA-mediated gene silencing pathways in C. elegans. Int. J. Biochem. Cell Biol. 2010 Aug; 42(8):1306-15.
- Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS ONE 2009; 4(12):e8210.
- Fischer SE, Butler MD, Pan Q, Ruvkun G. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature 2008 Sep 25; 455(7212):491-6.