Welcome to the Lee Lab! We are a collaborative team of molecular biologists, biochemists, cell biologists, and computational biologists. Together we study epigenetic regulation by long noncoding RNAs (lncRNA).


Our lab examines RNA function and mechanism through the lens of X-chromosome inactivation and imprinting, two classic epigenetic phenomena in which some of the first mammalian lncRNAs were discovered. What we do.

CLICK HERE. Left panel: Xist RNA spreads silencing along the X-chromosome by targeting chromatin modifiers such as Polycomb repressive complex 2 (PRC2). Right panel: Loss of Xist RNA in the blood compartment results in highly lethal blood cancers.

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