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CLICK HERE. Embryos deficient for Tsix and PRDM14 show delayed X-chromosome reactivation.

2017

Hongjae Sunwoo, David Colognori, John E. Froberg, Yesu Jeon, Jeannie T. Lee. Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1). Proc. Nat. Acad. Sci., USA 2017 Sept 18

Andrej J. Savol, Peggy I. Wang, Yesu Jeon, David Colognori, Eda Yildirim, Stefan F. Pinter, Bernhard Payer, Jeannie T. Lee, Ruslan Sadreyev. Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. PLoS One 2017 Aug 10

Hsueh-Ping Chu, John E. Froberg, Barry Kesner, Hyun Jung Oh, Fei Ji, Ruslan Sadreyev, Stefan F. Pinter, Jeannie T. Lee. PAR-TERRA directs homologous sex chromosome pairing. Nat Struc Mol Bio, USA 2017 Jul 10

Hsueh-Ping Chu, Catherine Cifuentes-Rojas, Barry Kesner, Eric Aeby, Hun-goo Lee, Chunyao Wei, Hyun Jung Oh, Myriam Boukhali, Wilhelm Haas, Jeannie T. Lee. TERRA RNA Antagonizes ATRX and Protects Telomeres. Cell, USA 2017 Jun 29

Chen-Yu Wang, John E. Froberg, Roy Blum, Yesu Jeon, Jeannie T. Lee. Comment on "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing". Science, USA 2017 Jun 16

Tedy Jégu, Eric Aeby, Jeannie T. Lee. The X chromosome in space. Nat Rev Genet., USA 2017 June

Sharmistha Kundu, Fei Ji, Hongjae Sunwoo, Gaurav Jain, Jeannie T. Lee, Ruslan I. Sadreyev, Job Dekker, Robert E. Kingston. Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Mol Cell, USA 2017 Feb 2

Smitha Sripathy, Vid Leko, Robin L. Adrianse, Taylor Loe, Eric J. Foss, Emily Dalrymple, Uyen Lao, Tonibelle Gatbonton-Schwager, Kelly T. Carter, Bernhard Payer, Patrick J. Paddison, William M. Grady, Jeannie T. Lee, Marisa S. Bartolomei, and Antonio Bedalov Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression. Proc. Nat. Acad. Sci., USA Epub 2017 Jan 31

2016

Athanasios Zovoilis, Catherine Cifuentes-Rojas, Hsueh-Ping Chu, Alfredo J. Hernandez and Jeannie T. Lee. Destabilization of B2 RNA by EZH2 Activates the Stress Response. Cell, USA 2016 Dec 15.

Derek Lessing, Thomas O. Dial, Chunyao Wei, Bernhard Payer, Liselot L.G. Carrette, Barry Kesner, Atilla Szanto, Ajit Jadhav, David J. Maloney, Anton Simeonov, Jimmy Theriault, Thomas Hasaka, Antonio Bedalov, Marisa S. Bartolomei and Jeannie T. Lee. A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proc. Nat. Acad. Sci., USA 2016 Oct 28.

Lin Yang, James E. Kirby, Hongjae Sunwoo and Jeannie T. Lee. Female mice lacking Xist RNA show partial dosage compensation and survive to term. Genes & Development, USA 2016 Aug 1.

2015

Sha Sun, Bernhard Payer, Satoshi Namekawa, Jee Young An, William Press, Jovani Catalan-Dibene, Hongjae Sunwoo and Jeannie T. Lee. Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line. Proc. Nat. Acad. Sci., USA 2015 Oct 21.

Hongjae Sunwoo, John. Y. Wu, and Jeannie T. Lee.The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggest a hit-and-run mechanism in mouse cells. Proc. Nat. Acad. Sci., USA 2015 July 20.

Anand Minajigi, John E. Froberg, Chunyao Wei, Hongjae Sunwoo, Barry Kesner, David Colognori, Derek Lessing, Bernhard Payer, Myriam Boukhali, Wilhelm Haas, and Jeannie T. Lee. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation. Science June 18 2015. Full text

Brian J. Beliveau, Alistair N. Boettiger, Maier S. Avendano, Ralf Jungmann, Ruth B. McCole, Eric F. Joyce, Caroline Kim-Kiselak, Frederic Bantignies, Chamith Y. Fonseka, Jelena Erceg, Mohammed A. Hannan, Hien G. Hoang, David Colognori, Jeannie T. Lee, William M. Shih, Peng Yin, Xiaowei Zhuang, and Chao-ting Wu. Single-molecule super resolution imaging of chromosomes and in situ haplotype visualization using oligopaint FISH probes. Nat. Comm. May 2015

Karyn E. O'Connell, Amy M. Mikkola, Aaron M.Stepanek, Andyna Vernet, Christopher D. Hall, Chia C. Sun, Eda Yildirim, John F. Staropoli, Jeannie T. Lee and Diane E. Brown. Practical murine hematopathology: A comparative review and implications for research. Comp. Med. May 2015

Stefan F. Pinter, David Colognori, Brian J. Beliveau, Ruslan I. Sadreyev, Bernhard Payer, Eda Yildirim, Chao-ting Wu, and Jeannie T. Lee. Allelic imbalance is a prevalent and tissue specific feature of the mouse transcriptome. Genetics 2015 Apr 9.

Verena K. Maier, Caitlin M. Feeney, Jordan E. Taylor, Amanda L. Creech, Jana W. Qiao, Attila Szanto, Partha P. Das, Nicholas Chevrier, Catherine Cifuentes-Rojas, Stuart H. Orkin, Steven A. Carr, Jacob D. Jaffe, Philipp Mertins, and Jeannie T. Lee. Functional proteomic analysis of repressive histone methyltransferase complexes PRC2 and G9a reveals ZNF518B as a G9A regulator. Mol Cell Proteomics 2015 Feb 13.

Chen Davidovich, Xueyin Wang, Catherine Cifuentes-Rojas. Karen J. Goodrich, Anne R. Gooding, Jeannie T. Lee, and Thomas R. Cech. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Mol Cell. 2015 Jan 14.

Johnny T. Kung, Barry Kesner, Jee Young An, Janice Y. Ahn, Catherine Cifuentes-Rojas, David Colognori, Yesu Jeon, Attila Szanto, Brian C. del Rosario, Stefan F. Pinter, Jennifer A. Erwin, and Jeannie T. Lee. Locus-specific targeting to the X chromosome revealed by the RNA interactome of CTCF. Mol Cell. 2015 Jan 7.

2014

Amanda L. Creech, Jordan E. Taylor, Verena K. Maier, Xiaoyun Wu, Caitlin M. Feeney, Namrata D. Udeshi, Sally E. Peach, Jesse S. Boehm, Jeannie T. Lee, Steven A. Carr, and Jacob D. Jaff. Building the connectivity map of epigenetics:Chromatin profiling by quantitative targeted mass spectrometry. Methods 2014 Nov 6.

Kavitha Sarma, Catherine Cifuentes-Rojas, Ayla Ergun, Amanda Del Rosario, Yesu Jeon, Forest White, Ruslan Sadreyev, and Jeannie T. Lee. ATRX directs binding of PRC2 to Xist RNA and polycomb targets. Cell 2014 Nov 6.

Bernhard Payer and Jeannie T. Lee. Coupling of X chromosome reactivation with the pluripotent stem cell state. RNA Biol 2014 Aug 19.

Tyler J. Broering, Kris G. Alavattam, Ruslan I. Sadreyev, Yosuke Ichijima, Yasuko Kato, Kazuteru Hasegawa, R. Daniel Camerini-Otero, Jeannie T. Lee, Paul R. Andreassen, and Satoshi H. Namekawa.BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis. J. Cell Biol 2014 Jun 9.

Catherine Cifuentes-Rojas, Alfredo J. Hernandez, Kavitha Sarma, and Jeannie T. Lee. Regulatory interactions between RNA and polycomb repressive complex 2. Mol Cell 2014 Epub May 29

Nadya Dimitrova, Jesse R. Zamudio, Robyn M. Jong, Dylan Soukup, Rebecca Resnick, Kavitha Sarma, Amanda J. Ward, Arun Raj, Jeannie T. Lee, Phillip A. Sharp, and Tyler Jacks. LincRNA-p21 activates p21 in cis to promote polycomb target gene expression and to enforce the G1/S checkpoint. Mol Cell 2014 Epub May 21

Lin Yang, John E. Froberg, Jeannie T. Lee. Long noncoding RNAs: Fresh perspectives into the RNA world. Trends Biochem Sci 2014 Jan; 39 (1): 35-43

 

2013

Bernhard Payer, Michael Rosenberg, Masashi Yamaji, Yukihiro Yabuta, Michiyo Koyanagi-Aoi, Katsuhiko Hayashi, Shinya Yamanaka, Mitinori Saitou, and Jeannie T. Lee. Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol Cell 2013 Epub Nov 21

Matthew D. Simon, Stefan F. Pinter, Rui Fang, Kavitha Sarma, Michael Rutenberg-Schoenberg, Sarah K. Bowman, Barry A. Kesner, Verena K. Maier, Robert E. Kingston, and Jeannie T. Lee. High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature 2013 Epub Oct 27

John E. Froberg, Lin Yang, and Jeannie T. Lee. Guided by RNAs: X-inactivation as a model for lncRNA function. J. Mol Biol 2013 Epub Jun 28

Sha Sun, Brian C. Del Rosario, Attila Szanto, Yuya Ogawa, Yesu Jeon, and Jeannie T. Lee. Jpx RNA Activates Xist by Evicting CTCF. Cell 2013 June 20: 1537–1551

Derek Lessing, Montserrat C. Anguera, and Jeannie T. Lee. X Chromosome Inactivation and Epigenetic Responses to Cellular Reprogramming. Annu Rev Genomics Hum Genet. 2013 Epub May 6.

Ruslan I. Sadreyev, Eda Yildirim , Stefan F. Pinter, and Jeannie T. Lee. Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. Proc. Natl. Acad. Sci. U S A. 2013 Apr 5

Johnny T.Y. Kung and Jeannie T. Lee. RNA in the loop. Dev Cell. 2013 Mar 25: 565-567

Jeannie T. Lee and Marisa S. Bartolomei. X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease. Cell 2013 Mar 14: 1308-1323.

Johnny T. Y. Kung, David Colognori, and Jeannie T. Lee. Long noncoding RNAs: Past, present, and future. Genetics 2013 Mar 1: 651- 669.

Eda Yildirim, James E. Kirby, Diane E. Brown, Francois E. Mercier, Ruslan I. Sadreyev, David T. Scadden, and Jeannie T. Lee. Xist RNA is a potent suppressor of hematologic cancer in mice. Cell 2013 Feb 14: 727-742.

 

2012

Jeannie T. Lee. Epigenetic Regulation by Long Noncoding RNAs. Science 2012 Dec 14: 1435-1439.

Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E. ALKBH1 is a Histone H2A Dioxygenase Involved in Neural Differentiation. Stem Cells. 2012 Epub Sep 7.

Pinter SF, Sadreyev RI, Yildirim E, Jeon Y, Ohsumi TO, Borowsky M, and Lee JT. Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations.Genome Res. 2012 Epub Sep 4.

Erwin JA, Del Rosario B, Payer B, Lee JT. An Ex Vivo Model for Imprinting: Mutually Exclusive Binding of Cdx2 and Oct4 as a Switch for Imprinted and Random X-inactivation. Genetics. 2012 Epub Aug 31.

Anguera MC, Sadreyev R, Zhang Z, Szanto A, Payer B, Sheridan SD, Kwok S, Haggarty SJ, Sur M, Alvarez J, Gimelbrant A, Mitalipova M, Kirby JE, Lee JT. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell. 2012 Jul 6;11(1):75-90.

Jeon Y, Sarma K, Lee JT. New and Xisting regulatory mechanisms of X chromosome inactivation.
Curr Opin Genet Dev. 2012 Epub Mar 15.

 

2011

Yildirim E, Sadreyev RI, Pinter SF, Lee JT. X-Chromosome Hyperactivation in Mammals Via Nonlinear Relationships Between Chromatin States and Transcription.Nat. Struct. Mol. Biol. Epub 2011 Dec 4.

Lee JT. Gracefully Ageing at 50, X Chromosome Inactivation Becomes a Paradigm for RNA and Chromatin Control. Nat Rev Mol Cell Biol. 2011 Nov 23;12(12):815-26.

Anguera MC, Ma W, Clift D, Namekawa S, Kelleher RJ. LeeJT. Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain. PLoS Genet. 2011 Sep;7(9):e1002248. Epub 2011 Sep 1.

Spencer RJ, Del Rosario BC, Pinter SF, Lessing D, Sadreyev RI, Lee JT. A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to the initiation of X chromosome inactivation. Genetics. 2011 Aug 11. [Epub ahead of print].

Jeon Y, Lee JT. YY1 tethers Xist RNA to the inactive X nucleation center.Cell. 2011 Jul 8; 146(1):119-33.

Payer B, Lee JT, Namekawa SH. X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Hum Genet. 2011 Aug;130(2):265-80. Epub 2011 Jun 12.

Kim DH, Jeon Y, Anguera MC, and Lee JT. X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes. Semin. Cell Dev. Biol. Mar. 3, 2011. [Epub ahead of print].

Namekawa Sh, and Lee JT. Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos. Nat. Protoc. 2011, Feb;6(3):270-284. [Epub Feb 10, 2010].

 

2010

Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Barowsky M, and Lee JT. Genome-wide identification of polycomb-associated RNAs by RIP-deq. Molecular Cell 2010 December; 40:939-953.

Sarma K, Levasseur P, Aristarkhov A, and Lee JT. Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome. Proc. Nat. Acad. Sci., USA 2010 Dec 6. [Epub ahead of print].

Nordstrand LM, Svärd J, Larsen E, Nilsen A, Ougland R, Furu K, Lein GF, Rognes T, Namekawa SH, Lee JT, and Klungland A. Mice lacking alkbh1 display sex-ratio. PLoS One. 2010 Nov 3;5(11):e13827.

Tian D, Sun S and Lee, JT.  The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivationCell. 2010 Oct 29; 143(3):390-413.

Ahn J and Lee JT.  Retinoic acid accelerates downregulaton of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient.   BMC Dev. Biol. 2010Aug 20; 10:90.

Sun S, Fukue Y, Nolen L, Sadreyev RI, and Lee JT. Characterization of Xpr (Xpct) reveals instability but no effects on X-chromosome pairing or Xist expression. Transcription 2010 1:1, 1-1;. July/August.

Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett, CB Young RA, Lee JT, Jaenisch R, and Mitalipova M.  Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.  Cell. 2010 May 18;141(5):872-873. [Epub May 13, 2010].

Lee JT. The X model of RNA's niche in epigenomic regulation. Cold Spring Harb. Perspect. Biol. 2010 Sept;2(9):a003749.

Paro R and Lee JT.  Extending the frontiers of epigenetic regulation. Curr. Opin. Genet. Dev. 2010 Apr; 20(2):107-109. [Epub ahead of print].

Namekawa SH, Payer B, Huynh KD, Jaenisch R and Lee JT.  Two-step imprinted X-inactivation: Repeat vs genic silencing in the mouse.  Mol Cell Biol. 2010 Jul;30(13):3187-3205.

Erwin JA and Lee JT. Characterization of X-chromosome inactivation status in human pluripotent stem cells. Curr. Protoc. Stem Cell Biol. 2010 Feb; Chapter 1:Unit 1 B.6.

 

2009

Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N.  Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009 Nov 6; 16(15):425-438.

Lee JT. Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome. Genes Dev. August 15, 2009 23:1831-1842.

Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature. 2009 July 2; 460:128-132. Epub June 17.

Namekawa SH and Lee JT. XY and ZW: Is meiotic sex chromosome inactivation the rule in evolution? PLoS Genet. 2009 5(5):e1000493.

Zhang L-F, Ogawa Y, Ahn JY, Namekawa SH, Silva SS, and Lee JT. Telomeric RNAs mark sex chromosomes in stem cell .Genetics 2009 July 182:685-698.

Shibata S and Lee JT. MacroRNAs in the epigenetic control of X-chromosome inactivation. In: Epigenomics, 2009. Editors: AC Ferguson-Smith, et al. (Springer, Netherlands). pp 187-214.

 

2008

Zhao J, Sun BK, Erwin JA, Song J-J, Lee TJ. Polycomb proteins targeted by a short repeat RNA to the mouse X-chromosome. Science 2008 Oct. 31; 322(5920):750-756.

Anguera MC, Liu M, Avruch J, Lee JT. Characterization of two Mst1-deficient mouse models. Dev Dyn. 2008 Nov.;237 (11):3424-2334.

Lee JT. Current Biology 2008, 18: R940-941.

Payer B and Lee JT. X-chromosome dosage compensation: How mammals keep the balance. Ann. Rev. Genetics 2008 Aug 26.

Lindroth AM, Park YJ, McLean CM, Dokshin GA, Persson JM, Herman H, Pasini D, Miró X, Donohoe ME, Lee JT, Helin K, Soloway PD. Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet. 2008 Aug 1;4(8):e1000145.

Erwin JA and Lee JT.  New twists in X-chromosome inactivation.  Curr. Opin. Cell. Biol.  2008 June;20(3):3349-55. 

Ogawa Y, Sun BK, Lee JT.  Intersection of the RNA interference and X-inactivation pathwaysScience.  2008 June 6;320(5881):1336-1341.

Tsai CL, Rowntree RK, Cohen DE, Lee JT.  Higher order chromatin structure at the X-inactivation center via looping DNA.  Dev.
Biol. 2008 July 15;319(2):416-415.

Silva SS, Rowntree RK, Mekhoubad S, Lee JT. X-chromosome inactivation and epigenetic fluidity in human embrynic stem cells. Proc. Natl. Acad. Sci., USA 2008, Mar 25; 105(12):4820-4825.


2007

Lin H, Gupta V, Vermilyea MD, Falciani F, Lee JT, O’Neill LP, Turner BM.  Dosage compensation in the mouse balances up-regulation and silencing of x-linked genes. PLos Biol. 2007 Dec; 5(12):e326.

Xu N, Donohoe ME, Silva SS, and Lee, JT.  Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein.Nature Genet. 2007 Nov;39(11):1309-1396. Epub2007 Oct 21.

Kim S, Namekawa SH,  Niswander LM, Ward JO, Lee JT, Bardwell, VJ, Zarkower D.  A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosisPLos Genet. 2007 Apr 20;3(4):e62.

Namekawa SH, VandeBerg JL, McCarrey JR, and Lee JT.  Sex chromosome silencing in the marsupial male germ lineProc. Natl. Acad. Sci., USA 2007, Jun 5; 104(23):9730-5.

Zhang LF, Huynh KD, and Lee JT.  Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing.  Cell. 2007 May 18; 129(4):693-706. 

Mikkelsen TS,….Lee JT,….Toh K.  Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequencesNature. 2007 May 10;447(7141):167-11.

Cohen DE, Davidow LS, Erwin JA, Xu N, Warshawsky D, and Lee JT. The DXPas34 repeat regulates random and imprinted X-inactivation. Dev Cell. 2007 Jan;12(1):57-71.

Donohoe ME, Zhang LF, Xu N, Shi Y, and Lee JT.  Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell. 2007 Jan 12;25(1):43-56.

Davidow LS, Breen M, Duke SE, Samollow PB, McCarrey JR, and Lee, JT.   The search for a marsupial XIC reveals a break with vertebrate synteny. Chromosome Res. 2007;15(2):137-46. Epub 2007 Mar 5.


2006

Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W. Epigenetic dynamics of the Kenq1 imprinted domain in the early embryo. Development. 2006 Nov;133 (21):4203-10.

Rowntree RK, Lee JT. Mapping of DNA replication origins to noncoding genes of the X-inactivation center. Mol Cell Biol. 2006 May;26(10):3707-17.

Namekawa SH, Park PJ, Zhang LF, Shima JE, McCarrey JR, Griswold MD, Lee JT. Postmeiotic sex chromatin in the male germline of mice. Curr Biol. 2006 Apr 4; 16(7):660-7.

Boumil RM, Ogawa Y, Sun BK, Huynh K.D., Lee J.T. Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice. Mol Cell Biol. 2006 Mar;26(6):2109-17.

Sun BK, Deaton AM, Lee JT. A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Mol Cell. 2006 Mar 3;21(5):617-28.

Xu N, Tsai CL, Lee JT. Transient homologous chromosome pairing marks the onset of X inactivation. Science. 2006 Feb 24;311(5764):1149-1152. Epub 2006 Jan 19.


2005

Lee JT. Regulation of X-chromosome counting by Tsix and Xite sequences. Science. 2005 Jul 29;309(5735):768-71.

Lee JT. Sex chromosome inactivation: the importance of pairing. Curr Biol. 2005 Apr 12;15(7):R249-52. Review.

Huynh KD, Lee JT. X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny. Nat Rev Genet. 2005 May;6(5):410-8. Review.

Stavropoulos N, Rowntree RK, Lee JT. Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation. Mol Cell Biol. 2005 Apr;25(7):2757-69.

 


2004

Shibata S, Lee JT. Tsix Transcription- versus RNA-Based Mechanisms in Xist Repression and Epigenetic Choice. Curr Biol. 2004 Oct 5;14(19):1747-54.

 


2003

Lee JT. X-chromosome inactivation: a multi-disciplinary approach. Semin Cell Dev Biol. 2003 Dec;14(6):311-2. No abstract available.

Huynh KD and Lee JT. Inheritance of a pre-inactivated paternal X-chromosome in early mouse embryos. Nature. 2003 Dec 18;426(6968):857-62. Epub 2003 Dec 7.

Lee, JT. Functional intergenic transcription: a case study of the X-inactivation centre. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29;358(1436):1417-23; discussion 1423.

Lee JT. Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting. Curr Biol. 2003 Mar 18;13(6):R242-54. Review.

Ogawa Y and Lee JT. Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Mol Cell. 2003 Mar;11(3):731-43.

O'Neill LP, Randall TE, Lavender J, Spotswood HT, Lee JT and Turner BM. X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. Hum Mol Genet. 2003 Aug 1;12(15):1783-90.

Shibata S and Lee JT. Characterization and quantitation of Tsix transcriptional variants: implications for the mechanism of antisense regulation. Hum Mol Genet. 2003 Jan 15;12(2):125-36.

Lee JT. Molecular biology: Complicity of gene and pseudogene. Nature. 2003 May 1;423(6935):26-8. No abstract available.

 


2002

Ogawa Y and Lee JT. Antisense regulation in X inactivation and autosomal imprinting. Cytogenet Genome Res. 2002;99(1-4):59-65. Review.

Lee JT. Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Nat Genet. 2002 Sep;32(1):195-200. Epub 2002 Jul 29.

Lee JT. Is X-chromosome inactivation a homology effect? Adv Genet. 2002;46:25-48. Review. No abstract available.

Chao W, Huynh KD, Spencer RJ, Davidow, LS and Lee JT. CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 2002 Jan 11;295(5553):345-7. Epub 2001 Dec 6.

Cohen DE and Lee JT. X-chromosome inactivation and the search for chromosome-wide silencers. Curr Opin Genet Dev. 2002 Apr;12(2):219-24. Review.

 


2001

Boumil R M and Lee JT. Forty years of decoding the silence in X- chromosome inactivation. Hum Mol Genet. 2001 Oct 1;10(20):2225-32. Review.

Huynh, K.D. and Lee, J.T. Imprinted X-inactivation in eutherians: a model of gametic execution and zygotic relaxation. Curr Opin Cell Biol. 2001 Dec;13(6):690-7. Review.

Stavropoulos N, Lu N and Lee JT.  A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. Proc. Natl. Acad. Sci., USA 2001, 98:10232-10237.

 


2000

Lee JT. Disruption of imprinted X-inactivation by parent-of-origin effects at Tsix. Cell. 2000 Sep 29;103(1):17-27.

Reizes B, Lee JT and Leder P. (2000) Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. Genomics. 2000 Jan 1;63(1):149-52.

 


1999

Lee JT, Davidow LS, and Warshawsky D. (1999), Tsix: Identification of a gene antisense to Xist at the X-inactivation center. Nat. Genet. 1999 Apr;21(4):400-4.

Lee JT and Lu N. Targeted mutagenesis of Tsix leads to nonrandom X- inactivation.Cell. 1999 Oct 1;99(1):47-57.

Lee JT, Lu N, and Han, Y. Genetic analysis of the mouse X inactivation center defines an 80 kb multifunctional domain. Proc Natl Acad Sci USA. 1999; 96:3836-41.

Warshawsky D, Stavropoulos N, and Lee JT. Further examination of the Xist promoter switch hypothesis in X-inactivation: Evidence against the existence and function of a Po promoter. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14424-9.

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