Oettinger Lab

Marjorie Oettinger, Ph.D.

Department of Molecular Biology
Simches Research Center
Boston, MA 02114

Phone: (617) 726-5967
Fax: (617) 726-5949
Email
Publications
    2012
  1. Balter BB, Ciccone DN, Oettinger MA, Selsing E. Mice lacking S? tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations. Mol. Immunol. 2012 Aug; 52(1):1-8.

  2. Yuan CC, Matthews AG, Jin Y, Chen CF, Chapman BA, Ohsumi TK, Glass KC, Kutateladze TG, Borowsky ML, Struhl K, Oettinger MA. Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes. Cell Rep 2012 Feb 23; 1(2):83-90.

  3. 2009
  4. Matthews AG, Oettinger MA. RAG: a recombinase diversified. Nat. Immunol. 2009 Aug; 10(8):817-21.

  5. Matthews AG, Oettinger MA. Regulation of RAG transposition. Adv. Exp. Med. Biol. 2009; 650:16-31.

  6. 2008
  7. Schatz DG, Oettinger MA, Baltimore D. Pillars article: the V(D)J recombination activating gene, RAG-1. 1989. J. Immunol. 2008 Jan 1; 180(1):5-18.

  8. 2007
  9. Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature 2007 Dec 13; 450(7172):1106-10.

  10. Ramón-Maiques S, Kuo AJ, Carney D, Matthews AG, Oettinger MA, Gozani O, Yang W. The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc. Natl. Acad. Sci. U.S.A. 2007 Nov 27; 104(48):18993-8.

  11. 2005
  12. Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP. A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J. Biol. Chem. 2005 Aug 5; 280(31):28701-10.

  13. Dai Y, Wong B, Yen YM, Oettinger MA, Kwon J, Johnson RC. Determinants of HMGB proteins required to promote RAG1/2-recombination signal sequence complex assembly and catalysis during V(D)J recombination. Mol. Cell. Biol. 2005 Jun; 25(11):4413-25.

  14. Clatworthy AE, Valencia-Burton MA, Haber JE, Oettinger MA. The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast. J. Biol. Chem. 2005 May 27; 280(21):20247-52.

  15. 2004
  16. Oettinger MA. Molecular biology: hairpins at split ends in DNA. Nature 2004 Dec 23; 432(7020):960-1.

  17. Patenge N, Elkin SK, Oettinger MA. ATP-dependent remodeling by SWI/SNF and ISWI proteins stimulates V(D)J cleavage of 5 S arrays. J. Biol. Chem. 2004 Aug 20; 279(34):35360-7.

  18. Oettinger MA. How to keep V(D)J recombination under control. Immunol. Rev. 2004 Aug; 200:165-81.

  19. Matthews AG, Elkin SK, Oettinger MA. Ordered DNA release and target capture in RAG transposition. EMBO J. 2004 Mar 10; 23(5):1198-206.

  20. Ciccone D, Oettinger M. Chromatin modifications as clues to the regulation of antigen receptor assembly. Novartis Found. Symp. 2004; 259:146-58; discussion 1.

  21. Ciccone DN, Morshead KB, Oettinger MA. Chromatin immunoprecipitation in the analysis of large chromatin domains across murine antigen receptor loci. Meth. Enzymol. 2004; 376:334-48.

  22. 2003
  23. Park EJ, Chan DW, Oettinger MA, Kwon J. DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner. Nucleic Acids Res. 2003 Dec 1; 31(23):6819-27.

  24. Montalbano A, Ogwaro KM, Tang A, Matthews AG, Larijani M, Oettinger MA, Feeney AJ. V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence. J. Immunol. 2003 Nov 15; 171(10):5296-304.

  25. Morshead KB, Ciccone DN, Taverna SD, Allis CD, Oettinger MA. Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc. Natl. Acad. Sci. U.S.A. 2003 Sep 30; 100(20):11577-82.

  26. Clatworthy AE, Valencia MA, Haber JE, Oettinger MA. V(D)J recombination and RAG-mediated transposition in yeast. Mol. Cell 2003 Aug; 12(2):489-99.

  27. Elkin SK, Matthews AG, Oettinger MA. The C-terminal portion of RAG2 protects against transposition in vitro. EMBO J. 2003 Apr 15; 22(8):1931-8.

  28. Dai Y, Kysela B, Hanakahi LA, Manolis K, Riballo E, Stumm M, Harville TO, West SC, Oettinger MA, Jeggo PA. Nonhomologous end joining and V(D)J recombination require an additional factor. Proc. Natl. Acad. Sci. U.S.A. 2003 Mar 4; 100(5):2462-7.

  29. Ng HH, Ciccone DN, Morshead KB, Oettinger MA, Struhl K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc. Natl. Acad. Sci. U.S.A. 2003 Feb 18; 100(4):1820-5.

  30. Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA. Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proc. Natl. Acad. Sci. U.S.A. 2003 Feb 4; 100(3):1209-14.

  31. 2002
  32. Mundy CL, Patenge N, Matthews AG, Oettinger MA. Assembly of the RAG1/RAG2 synaptic complex. Mol. Cell. Biol. 2002 Jan; 22(1):69-77.

  33. 2001
  34. O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, Hirsch B, Gennery A, Palmer SE, Seidel J, Gatti RA, Varon R, Oettinger MA, Neitzel H, Jeggo PA, Concannon P. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol. Cell 2001 Dec; 8(6):1175-85.

  35. Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA, Kysela B. Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity. J. Biol. Chem. 2001 Aug 17; 276(33):31124-32.

  36. Baldwin AS, Oettinger M, Struhl K. Methylation and uracil interference assays for analysis of protein-DNA interactions. Curr Protoc Mol Biol 2001 May; Chapter 12:Unit 12.3.

  37. 2000
  38. Kwon J, Morshead KB, Guyon JR, Kingston RE, Oettinger MA. Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA. Mol. Cell 2000 Nov; 6(5):1037-48.

  39. Kim DR, Park SJ, Oettinger MA. V(D)J recombination: site-specific cleavage and repair. Mol. Cells 2000 Aug 31; 10(4):367-74.

  40. 1999
  41. Kim DR, Dai Y, Mundy CL, Yang W, Oettinger MA. Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev. 1999 Dec 1; 13(23):3070-80.

  42. Oettinger MA. V(D)J recombination: on the cutting edge. Curr. Opin. Cell Biol. 1999 Jun; 11(3):325-9.

  43. Steen SB, Han JO, Mundy C, Oettinger MA, Roth DB. Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination. Mol. Cell. Biol. 1999 Apr; 19(4):3010-7.

  44. 1998
  45. Kwon J, Imbalzano AN, Matthews A, Oettinger MA. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1. Mol. Cell 1998 Dec; 2(6):829-39.

  46. Kirch SA, Rathbun GA, Oettinger MA. Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly. EMBO J. 1998 Aug 17; 17(16):4881-6.

  47. Akamatsu Y, Oettinger MA. Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences. Mol. Cell. Biol. 1998 Aug; 18(8):4670-8.

  48. Kim DR, Oettinger MA. Functional analysis of coordinated cleavage in V(D)J recombination. Mol. Cell. Biol. 1998 Aug; 18(8):4679-88.

  49. 1996
  50. Cuomo CA, Mundy CL, Oettinger MA. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol. Cell. Biol. 1996 Oct; 16(10):5683-90.

  51. Kirch SA, Sudarsanam P, Oettinger MA. Regions of RAG1 protein critical for V(D)J recombination. Eur. J. Immunol. 1996 Apr; 26(4):886-91.

  52. Oettinger MA. Cutting apart V(D)J recombination. Curr. Opin. Genet. Dev. 1996 Apr; 6(2):141-5.

  53. Gallay P, Stitt V, Mundy C, Oettinger M, Trono D. Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. J. Virol. 1996 Feb; 70(2):1027-32.

  54. 1995
  55. McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, Gellert M, Oettinger MA. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 1995 Nov 3; 83(3):387-95.

  56. Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, Oettinger MA, Brown JM. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 1995 Feb 24; 267(5201):1178-83.

  57. 1994
  58. Cuomo CA, Kirch SA, Gyuris J, Brent R, Oettinger MA. Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc. Natl. Acad. Sci. U.S.A. 1994 Jun 21; 91(13):6156-60.

  59. Cuomo CA, Oettinger MA. Analysis of regions of RAG-2 important for V(D)J recombination. Nucleic Acids Res. 1994 May 25; 22(10):1810-4.

  60. 1992
  61. Oettinger MA. Activation of V(D)J recombination by RAG1 and RAG2. Trends Genet. 1992 Dec; 8(12):413-6.

  62. Schatz DG, Oettinger MA, Schlissel MS. V(D)J recombination: molecular biology and regulation. Annu. Rev. Immunol. 1992; 10:359-83.

  63. Oettinger MA, Stanger B, Schatz DG, Glaser T, Call K, Housman D, Baltimore D. The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice. Immunogenetics 1992; 35(2):97-101.

  64. 1991
  65. Turka LA, Schatz DG, Oettinger MA, Chun JJ, Gorka C, Lee K, McCormack WT, Thompson CB. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science 1991 Aug 16; 253(5021):778-81.

  66. Hendrickson EA, Qin XQ, Bump EA, Schatz DG, Oettinger M, Weaver DT. A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc. Natl. Acad. Sci. U.S.A. 1991 May 15; 88(10):4061-5.

  67. Chun JJ, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell 1991 Jan 11; 64(1):189-200.

  68. Carlson LM, Oettinger MA, Schatz DG, Masteller EL, Hurley EA, McCormack WT, Baltimore D, Thompson CB. Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion. Cell 1991 Jan 11; 64(1):201-8.

  69. 1990
  70. Oettinger MA, Schatz DG, Gorka C, Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990 Jun 22; 248(4962):1517-23.

  71. 1989
  72. Schatz DG, Oettinger MA, Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell 1989 Dec 22; 59(6):1035-48.

  73. 1985
  74. Oettinger MA, Struhl K. Suppressors of Saccharomyces cerevisiae his3 promoter mutations lacking the upstream element. Mol. Cell. Biol. 1985 Aug; 5(8):1901-9.

  75. Struhl K, Chen W, Hill DE, Hope IA, Oettinger MA. Constitutive and coordinately regulated transcription of yeast genes: promoter elements, positive and negative regulatory sites, and DNA binding proteins. Cold Spring Harb. Symp. Quant. Biol. 1985; 50:489-503.

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