Ruvkun Lab

Gary Ruvkun, Ph.D.

Department of Molecular Biology
Simches Research Center
Boston, MA 02114

Phone: (617) 726-5959
Fax: (617) 726-5973

  1. Shi Z, Montgomery TA, Qi Y, Ruvkun G. High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res. 2013 Mar; 23(3):497-508.

  2. O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G. ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013 Feb 15; 27(4):429-40.

  3. Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G. Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature 2013 Jan 31; 493(7434):694-8.

  4. Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G. Radiation resistance of biological reagents for in situ life detection. Astrobiology 2013 Jan; 13(1):68-78.

  5. 2012
  6. Zhang C, Ruvkun G. New insights into siRNA amplification and RNAi. RNA Biol 2012 Aug 1; 9(8):1045-9.

  7. Shore DE, Carr CE, Ruvkun G. Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012 Jul; 8(7):e1002792.

  8. Phillips CM, Montgomery TA, Breen PC, Ruvkun G. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012 Jul 1; 26(13):1433-44.

  9. Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE. An image analysis toolbox for high-throughput C. elegans assays. Nat. Methods 2012 Jul; 9(7):714-6.

  10. Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification. Curr. Biol. 2012 May 22; 22(10):881-90.

  11. Melo JA, Ruvkun G. Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell 2012 Apr 13; 149(2):452-66.

  12. Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet. 2012 Apr; 8(4):e1002616.

  13. Shi Z, Ruvkun G. The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2012 Mar 20; 109(12):4568-73.

  14. Wu X, Shi Z, Cui M, Han M, Ruvkun G. Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet. 2012 Mar; 8(3):e1002542.

  15. Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP. Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. PLoS ONE 2012; 7(10):e48282.

  16. 2011
  17. Russel S, Frand AR, Ruvkun G. Regulation of the C. elegans molt by pqn-47. Dev. Biol. 2011 Dec 15; 360(2):297-309.

  18. Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G. The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. 2011 Nov; 7(11):e1002369.

  19. Hayes GD, Riedel CG, Ruvkun G. The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011 Oct 1; 25(19):2079-92.

  20. Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS. RNAi screening for fat regulatory genes with SRS microscopy. Nat. Methods 2011 Feb; 8(2):135-8.

  21. Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2011 Jan 25; 108(4):1201-8.

  22. Kimura KD, Riddle DL, Ruvkun G. The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status. Cold Spring Harb. Symp. Quant. Biol. 2011; 76:113-20.

  23. 2010
  24. Wu X, Ruvkun G. Cancer. Germ cell genes and cancer. Science 2010 Dec 24; 330(6012):1761-2.

  25. Meli VS, Osuna B, Ruvkun G, Frand AR. MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol. Biol. Cell 2010 May 15; 21(10):1648-61.

  26. 2009
  27. O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009 Nov; 10(5):430-5.

  28. Curran SP, Wu X, Riedel CG, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 2009 Jun 25; 459(7250):1079-84.

  29. Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009 Feb 15; 23(4):496-511.

  30. Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY. Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc. Natl. Acad. Sci. U.S.A. 2009 Feb 10; 106(6):1875-9.

  31. Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS ONE 2009; 4(12):e8210.

  32. 2008
  33. Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G. The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph 2008 Dec; 38(6):517-33.

  34. Wang MC, O'Rourke EJ, Ruvkun G. Fat metabolism links germline stem cells and longevity in C. elegans. Science 2008 Nov 7; 322(5903):957-60.

  35. Ruvkun G. The perfect storm of tiny RNAs. Nat. Med. 2008 Oct; 14(10):1041-5.

  36. Fischer SE, Butler MD, Pan Q, Ruvkun G. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature 2008 Sep 25; 455(7212):491-6.

  37. Ruvkun G. Tiny RNA: Where do we come from? What are we? Where are we going? Trends Plant Sci. 2008 Jul; 13(7):313-6.

  38. Patel DS, Fang LL, Svy DK, Ruvkun G, Li W. Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development 2008 Jul; 135(13):2239-49.

  39. Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell 2008 May 30; 133(5):903-15. Download PDF

  40. Gabel HW, Ruvkun G. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat. Struct. Mol. Biol. 2008 May; 15(5):531-3.

  41. Isenbarger TA, Finney M, Ríos-Velázquez C, Handelsman J, Ruvkun G. Miniprimer PCR, a new lens for viewing the microbial world. Appl. Environ. Microbiol. 2008 Feb; 74(3):840-9.

  42. Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA. MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol. Dev. ; 10(1):106-13.

  43. 2007
  44. Parry DH, Xu J, Ruvkun G. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr. Biol. 2007 Dec 4; 17(23):2013-22.

  45. Samuelson AV, Carr CE, Ruvkun G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 2007 Nov 15; 21(22):2976-94.

  46. Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY. Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics 2007 Oct; 177(2):835-45.

  47. Curran SP, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007 Apr 6; 3(4):e56.

  48. Ruvinsky I, Ohler U, Burge CB, Ruvkun G. Detection of broadly expressed neuronal genes in C. elegans. Dev. Biol. 2007 Feb 15; 302(2):617-26.

  49. Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G. Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harb. Symp. Quant. Biol. 2007; 72:489-97.

  50. 2006
  51. Hayes GD, Frand AR, Ruvkun G. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development 2006 Dec; 133(23):4631-41.

  52. Hu PJ, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006 Jul; 2(7):e99.

  53. Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat. Neurosci. 2006 May; 9(5):599-601.

  54. Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage. Nat. Genet. 2006 Mar; 38(3):363-8.

  55. Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell 2006 Jan 27; 124(2):343-54.

  56. Ruvkun G. Clarifications on miRNA and cancer. Science 2006 Jan 6; 311(5757):36-7.

  57. Hayes GD, Ruvkun G. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Cold Spring Harb. Symp. Quant. Biol. 2006; 71:21-7.

  58. 2005
  59. Frand AR, Russel S, Ruvkun G. Functional genomic analysis of C. elegans molting. PLoS Biol. 2005 Oct; 3(10):e312.

  60. Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. Systematic analysis of genes required for synapse structure and function. Nature 2005 Jul 28; 436(7050):510-7.

  61. Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature 2005 Jul 28; 436(7050):593-7.

  62. Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 2005 Jul 1; 19(13):1544-55.

  63. Ruvkun GB. The tiny RNA world. Harvey Lect. ; 99:1-21.

  64. Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science 2005 May 20; 308(5725):1164-7.

  65. Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P. Analysis of xbx genes in C. elegans. Development 2005 Apr; 132(8):1923-34.

  66. 2004
  67. Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat. Genet. 2004 Oct; 36(10):1079-83.

  68. Mak HY, Ruvkun G. Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development 2004 Apr; 131(8):1777-86.

  69. Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol. Cell 2004 Feb 27; 13(4):469-82.

  70. Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature 2004 Feb 12; 427(6975):645-9.

  71. Ruvkun G, Wightman B, Ha I. The 20 years it took to recognize the importance of tiny RNAs. Cell 2004 Jan 23; 116(2 Suppl):S93-6, 2 p following.

  72. Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc. Natl. Acad. Sci. U.S.A. 2004 Jan 6; 101(1):360-5.

  73. Wang D, Ruvkun G. Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb. Symp. Quant. Biol. 2004; 69:429-31.

  74. 2003
  75. Komaroff AL, Ruvkun G. Unraveling the secrets of the cell. Newsweek 2003 Dec 8; 142(23):96.

  76. Ruvinsky I, Ruvkun G. Functional tests of enhancer conservation between distantly related species. Development 2003 Nov; 130(21):5133-42.

  77. Sze JY, Ruvkun G. Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc. Natl. Acad. Sci. U.S.A. 2003 Aug 5; 100(16):9560-5.

  78. Aspöck G, Ruvkun G, Bürglin TR. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development 2003 Aug; 130(15):3369-78.

  79. Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev. Biol. 2003 Jul 1; 259(1):1-8.

  80. Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution? Evol. Dev. ; 5(4):372-8.

  81. Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science 2003 Jun 20; 300(5627):1921.

  82. Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J. Computational and experimental identification of C. elegans microRNAs. Mol. Cell 2003 May; 11(5):1253-63.

  83. Lee SS, Kennedy S, Tolonen AC, Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science 2003 Apr 25; 300(5619):644-7.

  84. Li W, Kennedy SG, Ruvkun G. daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 2003 Apr 1; 17(7):844-58.

  85. Ambros V, Bartel B, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T. A uniform system for microRNA annotation. RNA 2003 Mar; 9(3):277-9.

  86. Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 2003 Jan 16; 421(6920):268-72.

  87. Lee SS, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 2003 Jan; 33(1):40-8.

  88. 2002
  89. Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J. Biol. Chem. 2002 Dec 20; 277(51):49591-7.

  90. Sze JY, Zhang S, Li J, Ruvkun G. The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development 2002 Aug; 129(16):3901-11.

  91. Lee SS, Ruvkun G. Longevity: don't hold your breath. Nature 2002 Jul 18; 418(6895):287-8.

  92. Pasquinelli AE, Ruvkun G. Control of developmental timing by micrornas and their targets. Annu. Rev. Cell Dev. Biol. 2002; 18:495-513.

  93. 2001
  94. Lee RY, Hench J, Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 2001 Dec 11; 11(24):1950-7.

  95. Ruvkun G. Molecular biology. Glimpses of a tiny RNA world. Science 2001 Oct 26; 294(5543):797-9.

  96. Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 2001 Jul 13; 106(1):23-34.

  97. Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, Alexander-Bridges M. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J. Biol. Chem. 2001 Apr 20; 276(16):13402-10.

  98. Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001 Mar 15; 15(6):672-86.

  99. Bürglin TR, Ruvkun G. Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development 2001 Mar; 128(5):779-90.

  100. Reinhart BJ, Ruvkun G. Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics 2001 Jan; 157(1):199-209.

  101. Finch CE, Ruvkun G. The genetics of aging. Annu Rev Genomics Hum Genet 2001; 2:435-62.

  102. 2000
  103. Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 2000 Nov 2; 408(6808):86-9.

  104. Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR. Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Dev. Genes Evol. 2000 Nov; 210(11):564-9.

  105. Wolkow CA, Kimura KD, Lee MS, Ruvkun G. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 2000 Oct 6; 290(5489):147-50.

  106. Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc. Natl. Acad. Sci. U.S.A. 2000 Sep 12; 97(19):10412-7.

  107. Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol. Cell 2000 Apr; 5(4):659-69.

  108. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000 Feb 24; 403(6772):901-6.

  109. Sze JY, Victor M, Loer C, Shi Y, Ruvkun G. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature 2000 Feb 3; 403(6769):560-4.

  110. Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc. Natl. Acad. Sci. U.S.A. 2000 Jan 4; 97(1):460-5.

  111. 1999
  112. Davidson EH, Ruvkun G. Themes from a NASA workshop on gene regulatory processes in development and evolution. J. Exp. Zool. 1999 Aug 15; 285(2):104-15.

  113. Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI. Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev. 1999 Jul 15; 13(14):1794-806.

  114. Hobert O, Ruvkun G. Pax genes in Caenorhabditis elegans: a new twist. Trends Genet. 1999 Jun; 15(6):214-6.

  115. Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 1999 Jun 1; 13(11):1438-52.

  116. Hobert O, Tessmar K, Ruvkun G. The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development 1999 Apr; 126(7):1547-62.

  117. Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J. Cell Biol. 1999 Jan 11; 144(1):45-57.

  118. 1998
  119. Ruvkun G, Hobert O. The taxonomy of developmental control in Caenorhabditis elegans. Science 1998 Dec 11; 282(5396):2033-41.

  120. Slack FJ, Ruvkun G. A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem. Sci. 1998 Dec; 23(12):474-5.

  121. Ogg S, Ruvkun G. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 1998 Dec; 2(6):887-93.

  122. Slack F, Ruvkun G. Heterochronic genes in development and evolution. Biol. Bull. 1998 Dec; 195(3):375-6.

  123. Hobert O, Ruvkun G. A common theme for LIM homeobox gene function across phylogeny? Biol. Bull. 1998 Dec; 195(3):377-80.

  124. Guarente L, Ruvkun G, Amasino R. Aging, life span, and senescence. Proc. Natl. Acad. Sci. U.S.A. 1998 Sep 15; 95(19):11034-6.

  125. Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 1998 Aug 15; 12(16):2488-98.

  126. Hobert O, D'Alberti T, Liu Y, Ruvkun G. Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. J. Neurosci. 1998 Mar 15; 18(6):2084-96.

  127. Tissenbaum HA, Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 1998 Feb; 148(2):703-17.

  128. 1997
  129. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 1997 Oct 30; 389(6654):994-9.

  130. Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 1997 Oct 15; 11(20):2679-90.

  131. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997 Aug 15; 277(5328):942-6.

  132. Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 1997 Aug; 19(2):345-57.

  133. Sluder AE, Lindblom T, Ruvkun G. The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Dev. Biol. 1997 Apr 15; 184(2):303-19.

  134. Sze JY, Liu Y, Ruvkun G. VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development 1997 Mar; 124(6):1159-68.

  135. Slack F, Ruvkun G. Temporal pattern formation by heterochronic genes. Annu. Rev. Genet. 1997; 31:611-34.

  136. 1996
  137. Ha I, Wightman B, Ruvkun G. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes Dev. 1996 Dec 1; 10(23):3041-50.

  138. Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 1996 Aug 8; 382(6591):536-9.

  139. Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S. The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J. Neurochem. 1996 Jul; 67(1):46-57.

  140. Baumeister R, Liu Y, Ruvkun G. Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes Dev. 1996 Jun 1; 10(11):1395-410.

  141. 1994
  142. Greenstein D, Hird S, Plasterk RH, Andachi Y, Kohara Y, Wang B, Finney M, Ruvkun G. Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Genes Dev. 1994 Aug 15; 8(16):1935-48.

  143. Gottlieb S, Ruvkun G. daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics 1994 May; 137(1):107-20.

  144. 1993
  145. Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993 Dec 3; 75(5):855-62.

  146. Bürglin TR, Ruvkun G. The Caenorhabditis elegans homeobox gene cluster. Curr. Opin. Genet. Dev. 1993 Aug; 3(4):615-20.

  147. 1992
  148. Ruvkun G. Cell signalling. A molecular growth industry. Nature ; 360(6406):711-2.

  149. Xue D, Finney M, Ruvkun G, Chalfie M. Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. EMBO J. 1992 Dec; 11(13):4969-79.

  150. Bürglin TR, Ruvkun G. New motif in PBX genes. Nat. Genet. 1992 Aug; 1(5):319-20.

  151. Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L. C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature 1992 Feb 27; 355(6363):841-5.

  152. 1991
  153. Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G. Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development. Genes Dev. 1991 Oct; 5(10):1813-24.

  154. Arasu P, Wightman B, Ruvkun G. Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28. Genes Dev. 1991 Oct; 5(10):1825-33.

  155. Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH. Nematode homeobox cluster. Nature 1991 Jun 27; 351(6329):703.

  156. Ruvkun G, Finney M. Regulation of transcription and cell identity by POU domain proteins. Cell 1991 Feb 8; 64(3):475-8.

  157. Ruvkun G, Wightman B, Bürglin T, Arasu P. Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes. Dev. Suppl. 1991; 1:47-54.

  158. 1990
  159. Finney M, Ruvkun G. The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell 1990 Nov 30; 63(5):895-905.

  160. Ruvkun G, Gilbert W, Horvitz HR. Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Res. 1990 Feb 25; 18(4):809-15.

  161. 1989
  162. Bürglin TR, Finney M, Coulson A, Ruvkun G. Caenorhabditis elegans has scores of homoeobox-containing genes. Nature 1989 Sep 21; 341(6239):239-43.

  163. Ruvkun G, Giusto J. The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature 1989 Mar 23; 338(6213):313-9.

  164. Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR. Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics 1989 Mar; 121(3):501-16.

  165. 1988
  166. Finney M, Ruvkun G, Horvitz HR. The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell 1988 Dec 2; 55(5):757-69.

  167. Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev. 1988 Dec; 2(12A):1513-6.

  168. 1982
  169. Ruvkun GB, Sundaresan V, Ausubel FM. Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes. Cell 1982 Jun; 29(2):551-9.

  170. Ruvkun GB, Sundaresan V, Ausubel FM. Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts. Gene 1982 Jun; 18(3):247-55.

  171. Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM. ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes. J. Mol. Appl. Genet. 1982; 1(5):405-18.

  172. Meade HM, Long SR, Ruvkun GB, Brown SE, Ausubel FM. Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis. J. Bacteriol. 1982 Jan; 149(1):114-22.

  173. 1981
  174. Ruvkun GB, Ausubel FM. A general method for site-directed mutagenesis in prokaryotes. Nature 1981 Jan 1; 289(5793):85-8.

  175. 1980
  176. Ruvkun GB, Ausubel FM. Interspecies homology of nitrogenase genes. Proc. Natl. Acad. Sci. U.S.A. 1980 Jan; 77(1):191-5.

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