Szostak Lab

Jack Szostak, Ph.D.

Department of Molecular Biology
Simches Research Center
Boston, MA 02114

Phone: (617) 643-7581
Fax: (617) 726-6893
Email

Website
Publications
    2013
  1. Zhang S, Blain JC, Szostak JW. Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension. J. Am. Chem. Soc. 2013 Jan 16; 135(2):924-32.

    2. 2012
  2. Budin I, Debnath A, Szostak JW. Concentration-driven growth of model protocell membranes. J. Am. Chem. Soc. 2012 Dec 26; 134(51):20812-9.

  3. Powner MW, Zheng SL, Szostak JW. Multicomponent assembly of proposed DNA precursors in water. J. Am. Chem. Soc. 2012 Aug 22; 134(33):13889-95.

  4. Schlippe YV, Hartman MC, Josephson K, Szostak JW. In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors. J. Am. Chem. Soc. 2012 Jun 27; 134(25):10469-77.

  5. Zhu TF, Adamala K, Zhang N, Szostak JW. Photochemically driven redox chemistry induces protocell membrane pearling and division. Proc. Natl. Acad. Sci. U.S.A. 2012 Jun 19; 109(25):9828-32.

  6. Hofmann FT, Szostak JW, Seebeck FP. In vitro selection of functional lantipeptides. J. Am. Chem. Soc. 2012 May 16; 134(19):8038-41.

  7. Zhang N, Szostak JW. Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template. J. Am. Chem. Soc. 2012 Feb 29; 134(8):3691-4.

  8. Szostak JW. Attempts to define life do not help to understand the origin of life. J. Biomol. Struct. Dyn. 2012 Feb; 29(4):599-600.

    9. 2011
  9. Szostak JW. An optimal degree of physical and chemical heterogeneity for the origin of life? Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2011 Oct 27; 366(1580):2894-901.

  10. Trevino SG, Zhang N, Elenko MP, Lupták A, Szostak JW. Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity. Proc. Natl. Acad. Sci. U.S.A. 2011 Aug 16; 108(33):13492-7.

  11. Seebeck FP, Ricardo A, Szostak JW. Artificial lantipeptides from in vitro translations. Chem. Commun. (Camb.) 2011 Jun 7; 47(21):6141-3.

  12. Budin I, Szostak JW. Physical effects underlying the transition from primitive to modern cell membranes. Proc. Natl. Acad. Sci. U.S.A. 2011 Mar 29; 108(13):5249-54.

  13. Subtelny AO, Hartman MC, Szostak JW. Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation. Angew. Chem. Int. Ed. Engl. 2011 Mar 28; 50(14):3164-7.

    14. 2010
  14. Powner MW, Sutherland JD, Szostak JW. Chemoselective multicomponent one-pot assembly of purine precursors in water. J. Am. Chem. Soc. 2010 Nov 24; 132(46):16677-88.

  15. Szostak JW. DNA ends: just the beginning (Nobel lecture). Angew. Chem. Int. Ed. Engl. 2010 Oct 4; 49(41):7386-404.

  16. Schrum JP, Zhu TF, Szostak JW. The origins of cellular life. Cold Spring Harb Perspect Biol 2010 Sep; 2(9):a002212.

  17. Elenko MP, Szostak JW, van Oijen AM. Single-molecule binding experiments on long time scales. Rev Sci Instrum 2010 Aug; 81(8):083705.

  18. Budin I, Szostak JW. Expanding roles for diverse physical phenomena during the origin of life. Annu Rev Biophys 2010 Jun 9; 39:245-63.

  19. Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J. Am. Chem. Soc. 2010 Apr 28; 132(16):5880-5.

    20. 2009
  20. Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L, Szostak JW. Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Biophys. J. 2009 Dec 16; 97(12):3113-22.

  21. Schrum JP, Ricardo A, Krishnamurthy M, Blain JC, Szostak JW. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers. J. Am. Chem. Soc. 2009 Oct 14; 131(40):14560-70.

  22. Lin S, Horning DP, Szostak JW, Chaput JC. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. J Phys Chem A 2009 Sep 3; 113(35):9585-7.

  23. Ricardo A, Szostak JW. Origin of life on earth. Sci. Am. 2009 Sep; 301(3):54-61.

  24. Elenko MP, Szostak JW, van Oijen AM. Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics. J. Am. Chem. Soc. 2009 Jul 29; 131(29):9866-7.

  25. Budin I, Bruckner RJ, Szostak JW. Formation of protocell-like vesicles in a thermal diffusion column. J. Am. Chem. Soc. 2009 Jul 22; 131(28):9628-9.

  26. Szostak JW. Origins of life: Systems chemistry on early Earth. Nature 2009 May 14; 459(7244):171-2.

  27. Zhu TF, Szostak JW. Coupled growth and division of model protocell membranes. J. Am. Chem. Soc. 2009 Apr 22; 131(15):5705-13.

  28. Chen JJ, Cai X, Szostak JW. N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system. J. Am. Chem. Soc. 2009 Feb 18; 131(6):2119-21.

  29. Szostak J. Ray Wu, as remembered by a former student. Sci. China, C, Life Sci. 2009 Feb; 52(2):108-10.

  30. Mansy SS, Szostak JW. Reconstructing the emergence of cellular life through the synthesis of model protocells. Cold Spring Harb. Symp. Quant. Biol. 2009; 74:47-54.

  31. Zhu TF, Szostak JW. Preparation of large monodisperse vesicles. PLoS ONE 2009; 4(4):e5009.

  32. Chen JJ, Tsai CH, Cai X, Horhota AT, McLaughlin LW, Szostak JW. Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. PLoS ONE 2009; 4(3):e4949.

    33. 2008
  33. Mansy SS, Szostak JW. Thermostability of model protocell membranes. Proc. Natl. Acad. Sci. U.S.A. 2008 Sep 9; 105(36):13351-5.

  34. Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW. Template-directed synthesis of a genetic polymer in a model protocell. Nature 2008 Jul 3; 454(7200):122-5.

  35. Subtelny AO, Hartman MC, Szostak JW. Ribosomal synthesis of N-methyl peptides. J. Am. Chem. Soc. 2008 May 14; 130(19):6131-6.

  36. Monnard PA, Szostak JW. Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization. J. Inorg. Biochem. ; 102(5-6):1104-11.

    37. 2007
  37. Tsai CH, Chen J, Szostak JW. Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template. Proc. Natl. Acad. Sci. U.S.A. 2007 Sep 11; 104(37):14598-603.

  38. Seelig B, Szostak JW. Selection and evolution of enzymes from a partially randomized non-catalytic scaffold. Nature 2007 Aug 16; 448(7155):828-31.

  39. Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. J. Mol. Biol. 2007 Aug 10; 371(2):501-13.

  40. Hazen RM, Griffin PL, Carothers JM, Szostak JW. Functional information and the emergence of biocomplexity. Proc. Natl. Acad. Sci. U.S.A. 2007 May 15; 104 Suppl 1:8574-81.

  41. Meena , Sam M, Pierce K, Szostak JW, McLaughlin LW. 2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. Org. Lett. 2007 Mar 15; 9(6):1161-3.

  42. Hanczyc MM, Mansy SS, Szostak JW. Mineral surface directed membrane assembly. Orig Life Evol Biosph 2007 Feb; 37(1):67-82.

  43. Hartman MC, Josephson K, Lin CW, Szostak JW. An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides. PLoS ONE 2007; 2(10):e972.

  44. Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC. Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS ONE 2007; 2(5):e467.

    45. 2006
  45. Horhota AT, Szostak JW, McLaughlin LW. Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities. Org. Lett. 2006 Nov 9; 8(23):5345-7.

  46. Blackburn EH, Greider CW, Szostak JW. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat. Med. 2006 Oct; 12(10):1133-8.

  47. Salehi-Ashtiani K, Lupták A, Litovchick A, Szostak JW. A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene. Science 2006 Sep 22; 313(5794):1788-92.

  48. Carothers JM, Oestreich SC, Szostak JW. Aptamers selected for higher-affinity binding are not more specific for the target ligand. J. Am. Chem. Soc. 2006 Jun 21; 128(24):7929-37.

  49. Seebeck FP, Szostak JW. Ribosomal synthesis of dehydroalanine-containing peptides. J. Am. Chem. Soc. 2006 Jun 7; 128(22):7150-1.

  50. Carothers JM, Davis JH, Chou JJ, Szostak JW. Solution structure of an informationally complex high-affinity RNA aptamer to GTP. RNA 2006 Apr; 12(4):567-79.

  51. Hartman MC, Josephson K, Szostak JW. Enzymatic aminoacylation of tRNA with unnatural amino acids. Proc. Natl. Acad. Sci. U.S.A. 2006 Mar 21; 103(12):4356-61.

  52. Cho GS, Szostak JW. Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. Chem. Biol. 2006 Feb; 13(2):139-47.

    53. 2005
  53. Fujikawa SM, Chen IA, Szostak JW. Shrink-wrap vesicles. Langmuir 2005 Dec 20; 21(26):12124-9.

  54. Chen IA, Salehi-Ashtiani K, Szostak JW. RNA catalysis in model protocell vesicles. J. Am. Chem. Soc. 2005 Sep 28; 127(38):13213-9.

  55. Josephson K, Hartman MC, Szostak JW. Ribosomal synthesis of unnatural peptides. J. Am. Chem. Soc. 2005 Aug 24; 127(33):11727-35.

  56. Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC. Kinetic analysis of an efficient DNA-dependent TNA polymerase. J. Am. Chem. Soc. 2005 May 25; 127(20):7427-34.

  57. Shen X, Valencia CA, Szostak JW, Dong B, Liu R. Scanning the human proteome for calmodulin-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 2005 Apr 26; 102(17):5969-74.

  58. Sacerdote MG, Szostak JW. Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose. Proc. Natl. Acad. Sci. U.S.A. 2005 Apr 26; 102(17):6004-8.

  59. Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW. Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs). Org. Lett. 2005 Apr 14; 7(8):1485-7.

  60. Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW. An in vitro selection system for TNA. J. Am. Chem. Soc. 2005 Mar 9; 127(9):2802-3.

  61. Plummer KA, Carothers JM, Yoshimura M, Szostak JW, Verdine GL. In vitro selection of RNA aptamers against a composite small molecule-protein surface. Nucleic Acids Res. 2005; 33(17):5602-10.

  62. Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak JW. High fidelity TNA synthesis by Therminator polymerase. Nucleic Acids Res. 2005; 33(16):5219-25.

    63. 2004
  63. Hanczyc MM, Szostak JW. Replicating vesicles as models of primitive cell growth and division. Curr Opin Chem Biol 2004 Dec; 8(6):660-4.

  64. Chen IA, Roberts RW, Szostak JW. The emergence of competition between model protocells. Science 2004 Sep 3; 305(5689):1474-6.

  65. Chen IA, Szostak JW. A kinetic study of the growth of fatty acid vesicles. Biophys. J. 2004 Aug; 87(2):988-98.

  66. Sazani PL, Larralde R, Szostak JW. A small aptamer with strong and specific recognition of the triphosphate of ATP. J. Am. Chem. Soc. 2004 Jul 14; 126(27):8370-1.

  67. Chaput JC, Szostak JW. Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. Chem. Biol. 2004 Jun; 11(6):865-74.

  68. Chen IA, Szostak JW. Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Proc. Natl. Acad. Sci. U.S.A. 2004 May 25; 101(21):7965-70.

  69. Carothers JM, Oestreich SC, Davis JH, Szostak JW. Informational complexity and functional activity of RNA structures. J. Am. Chem. Soc. 2004 Apr 28; 126(16):5130-7.

    70. 2003
  70. Huang Z, Szostak JW. Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. RNA 2003 Dec; 9(12):1456-63.

  71. Hanczyc MM, Fujikawa SM, Szostak JW. Experimental models of primitive cellular compartments: encapsulation, growth, and division. Science 2003 Oct 24; 302(5645):618-22.

  72. Chaput JC, Szostak JW. TNA synthesis by DNA polymerases. J. Am. Chem. Soc. 2003 Aug 6; 125(31):9274-5.

  73. Vaish NK, Larralde R, Fraley AW, Szostak JW, McLaughlin LW. A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. Biochemistry 2003 Jul 29; 42(29):8842-51.

  74. Szostak JW. Functional information: Molecular messages. Nature 2003 Jun 12; 423(6941):689.

  75. Huang Z, Szostak JW. Selective labeling and detection of specific RNAs in an RNA mixture. Anal. Biochem. 2003 Apr 1; 315(1):129-33.

  76. Chaput JC, Ichida JK, Szostak JW. DNA polymerase-mediated DNA synthesis on a TNA template. J. Am. Chem. Soc. 2003 Jan 29; 125(4):856-7.

    77. 2002
  77. Szostak JW. Molecular biology: RNA gets a grip on translation. Nature 2002 Oct 31; 419(6910):890-1.

  78. Davis JH, Szostak JW. Isolation of high-affinity GTP aptamers from partially structured RNA libraries. Proc. Natl. Acad. Sci. U.S.A. 2002 Sep 3; 99(18):11616-21.

  79. Baggio R, Burgstaller P, Hale SP, Putney AR, Lane M, Lipovsek D, Wright MC, Roberts RW, Liu R, Szostak JW, Wagner RW. Identification of epitope-like consensus motifs using mRNA display. J. Mol. Recognit. ; 15(3):126-34.

    80. 2001
  80. Keefe AD, Wilson DS, Seelig B, Szostak JW. One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. Protein Expr. Purif. 2001 Dec; 23(3):440-6.

  81. Salehi-Ashtiani K, Szostak JW. In vitro evolution suggests multiple origins for the hammerhead ribozyme. Nature 2001 Nov 1; 414(6859):82-4.

  82. Keefe AD, Szostak JW. Functional proteins from a random-sequence library. Nature 2001 Apr 5; 410(6829):715-8.

  83. Wilson DS, Keefe AD, Szostak JW. The use of mRNA display to select high-affinity protein-binding peptides. Proc. Natl. Acad. Sci. U.S.A. 2001 Mar 27; 98(7):3750-5.

  84. Szostak JW, Bartel DP, Luisi PL. Synthesizing life. Nature 2001 Jan 18; 409(6818):387-90.

    85. 2000
  85. Vaish NK, Fraley AW, Szostak JW, McLaughlin LW. Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. Nucleic Acids Res. 2000 Sep 1; 28(17):3316-22.

  86. Cho G, Keefe AD, Liu R, Wilson DS, Szostak JW. Constructing high complexity synthetic libraries of long ORFs using in vitro selection. J. Mol. Biol. 2000 Mar 24; 297(2):309-19.

  87. Lee N, Bessho Y, Wei K, Szostak JW, Suga H. Ribozyme-catalyzed tRNA aminoacylation. Nat. Struct. Biol. 2000 Jan; 7(1):28-33.

  88. Liu R, Barrick JE, Szostak JW, Roberts RW. Optimized synthesis of RNA-protein fusions for in vitro protein selection. Meth. Enzymol. 2000; 318:268-93.

    89. 1999
  89. Wilson DS, Szostak JW. In vitro selection of functional nucleic acids. Annu. Rev. Biochem. 1999; 68:611-47.

    90. 1998
  90. Wilson C, Szostak JW. Isolation of a fluorophore-specific DNA aptamer with weak redox activity. Chem. Biol. 1998 Nov; 5(11):609-17.

  91. Wilson C, Nix J, Szostak J. Functional requirements for specific ligand recognition by a biotin-binding RNA pseudoknot. Biochemistry 1998 Oct 13; 37(41):14410-9.

  92. Suga H, Cowan JA, Szostak JW. Unusual metal ion catalysis in an acyl-transferase ribozyme. Biochemistry 1998 Jul 14; 37(28):10118-25.

  93. Suga H, Lohse PA, Szostak JW. Structural and kinetic characterization of an acyl transferase ribozyme. J. Am. Chem. Soc. 1998 Feb 18; 120(6):1151-6.

  94. Holeman LA, Robinson SL, Szostak JW, Wilson C. Isolation and characterization of fluorophore-binding RNA aptamers. Fold Des 1998; 3(6):423-31.

    95. 1997
  95. Roberts RW, Szostak JW. RNA-peptide fusions for the in vitro selection of peptides and proteins. Proc. Natl. Acad. Sci. U.S.A. 1997 Nov 11; 94(23):12297-302.

  96. Dieckmann T, Butcher SE, Sassanfar M, Szostak JW, Feigon J. Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding. J. Mol. Biol. 1997 Oct 24; 273(2):467-78.

  97. Hager AJ, Szostak JW. Isolation of novel ribozymes that ligate AMP-activated RNA substrates. Chem. Biol. 1997 Aug; 4(8):607-17.

  98. Szostak JW. Introduction: Combinatorial Chemistry. Chem. Rev. 1997 Apr 1; 97(2):347-348.

  99. Szostak JW. In vitro selection and directed evolution. Harvey Lect. ; 93:95-118.

    100. 1996
  100. Huang Z, Szostak JW. A simple method for 3'-labeling of RNA. Nucleic Acids Res. 1996 Nov 1; 24(21):4360-1.

  101. Hager AJ, Pollard JD, Szostak JW. Ribozymes: aiming at RNA replication and protein synthesis. Chem. Biol. 1996 Sep; 3(9):717-25.

  102. Lohse PA, Szostak JW. Ribozyme-catalysed amino-acid transfer reactions. Nature 1996 May 30; 381(6581):442-4.

  103. Rohatgi R, Bartel DP, Szostak JW. Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. J. Am. Chem. Soc. 1996 Apr 10; 118(14):3332-9.

  104. Rohatgi R, Bartel DP, Szostak JW. Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. J. Am. Chem. Soc. 1996 Apr 10; 118(14):3340-4.

  105. Lorsch JR, Szostak JW. Chance and necessity in the selection of nucleic acid catalysts. Acc. Chem. Res. 1996 Feb; 29(2):103-10.

    106. 1995
  106. Lorsch JR, Szostak JW. Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme. Biochemistry 1995 Nov 21; 34(46):15315-27.

  107. Lorsch JR, Bartel DP, Szostak JW. Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template. Nucleic Acids Res. 1995 Aug 11; 23(15):2811-4.

  108. Ekland EH, Szostak JW, Bartel DP. Structurally complex and highly active RNA ligases derived from random RNA sequences. Science 1995 Jul 21; 269(5222):364-70.

  109. Cuenoud B, Szostak JW. A DNA metalloenzyme with DNA ligase activity. Nature 1995 Jun 15; 375(6532):611-4.

  110. Chapman KB, Szostak JW. Isolation of a ribozyme with 5'-5' ligase activity. Chem. Biol. 1995 May; 2(5):325-33.

  111. Wilson C, Szostak JW. In vitro evolution of a self-alkylating ribozyme. Nature 1995 Apr 27; 374(6525):777-82.

  112. Whoriskey SK, Usman N, Szostak JW. Total chemical synthesis of a ribozyme derived from a group I intron. Proc. Natl. Acad. Sci. U.S.A. 1995 Mar 28; 92(7):2465-9.

  113. Lauhon CT, Szostak JW. RNA aptamers that bind flavin and nicotinamide redox cofactors. J. Am. Chem. Soc. 1995 Feb 1; 117(4):1246-57.

  114. Huizenga DE, Szostak JW. A DNA aptamer that binds adenosine and ATP. Biochemistry 1995 Jan 17; 34(2):656-65.

    115. 1994
  115. Hanna M, Szostak JW. Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. Nucleic Acids Res. 1994 Dec 11; 22(24):5326-31.

  116. Lorsch JR, Szostak JW. In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature 1994 Sep 1; 371(6492):31-6.

  117. Peterson RD, Bartel DP, Szostak JW, Horvath SJ, Feigon J. 1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element. Biochemistry 1994 May 10; 33(18):5357-66.

  118. Lin CW, Hanna M, Szostak JW. Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding. Biochemistry 1994 Mar 8; 33(9):2703-7.

  119. Lorsch JR, Szostak JW. In vitro selection of RNA aptamers specific for cyanocobalamin. Biochemistry 1994 Feb 1; 33(4):973-82.

  120. Green R, Szostak JW. In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. J. Mol. Biol. 1994 Jan 7; 235(1):140-55.

  121. Chapman KB, Szostak JW. In vitro selection of catalytic RNAs. Curr. Opin. Struct. Biol. 1994; 4:618-22.

    122. 1993
  122. Bartel DP, Szostak JW. Isolation of new ribozymes from a large pool of random sequences [see comment]. Science 1993 Sep 10; 261(5127):1411-8.

  123. Sassanfar M, Szostak JW. An RNA motif that binds ATP. Nature 1993 Aug 5; 364(6437):550-3.

  124. Doudna JA, Usman N, Szostak JW. Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. Biochemistry 1993 Mar 2; 32(8):2111-5.

  125. Szostak JW. Ribozymes. Evolution ex vivo. Nature 1993 Jan 14; 361(6408):119-20.

    126. 1992
  126. Green R, Szostak JW. Selection of a ribozyme that functions as a superior template in a self-copying reaction. Science 1992 Dec 18; 258(5090):1910-5.

  127. Ross LO, Treco D, Nicolas A, Szostak JW, Dawson D. Meiotic recombination on artificial chromosomes in yeast. Genetics 1992 Jul; 131(3):541-50.

  128. Park EC, Szostak JW. ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J. 1992 Jun; 11(6):2087-93.

  129. Szostak JW. In vitro genetics. Trends Biochem. Sci. 1992 Mar; 17(3):89-93.

  130. Ellington AD, Szostak JW. Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures. Nature 1992 Feb 27; 355(6363):850-2.

  131. Park EC, Finley D, Szostak JW. A strategy for the generation of conditional mutations by protein destabilization. Proc. Natl. Acad. Sci. U.S.A. 1992 Feb 15; 89(4):1249-52.

    132. 1991
  132. Sun H, Dawson D, Szostak JW. Genetic and physical analyses of sister chromatid exchange in yeast meiosis. Mol. Cell. Biol. 1991 Dec; 11(12):6328-36.

  133. Bartel DP, Zapp ML, Green MR, Szostak JW. HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell 1991 Nov 1; 67(3):529-36.

  134. Green R, Szostak JW, Benner SA, Rich A, Usman N. Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. Nucleic Acids Res. 1991 Aug 11; 19(15):4161-6.

  135. Bartel DP, Doudna JA, Usman N, Szostak JW. Template-directed primer extension catalyzed by the Tetrahymena ribozyme. Mol. Cell. Biol. 1991 Jun; 11(6):3390-4.

  136. Doudna JA, Couture S, Szostak JW. A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. Science 1991 Mar 29; 251(5001):1605-8.

  137. Sun H, Treco D, Szostak JW. Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site. Cell 1991 Mar 22; 64(6):1155-61.

  138. Pace U, Szostak JW. Mutations in a semiconserved region of the Tetrahymena intron. FEBS Lett. 1991 Mar 11; 280(1):171-4.

  139. Schultes NP, Szostak JW. A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae. Mol. Cell. Biol. 1991 Jan; 11(1):322-8.

    140. 1990
  140. Schultes NP, Ellington AD, Cherry JM, Szostak JW. Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. Gene 1990 Dec 15; 96(2):177-80.

  141. Schultes NP, Szostak JW. Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast. Genetics 1990 Dec; 126(4):813-22.

  142. Doudna JA, Szostak JW, Rich A, Usman N. Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. J. Org. Chem. 1990 Oct 12; 55(21):5547-9.

  143. Michel F, Ellington AD, Couture S, Szostak JW. Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns. Nature 1990 Oct 11; 347(6293):578-80.

  144. Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW. Mutational analysis of conserved nucleotides in a self-splicing group I intron. J. Mol. Biol. 1990 Oct 5; 215(3):345-58.

  145. Lichten M, Goyon C, Schultes NP, Treco D, Szostak JW, Haber JE, Nicolas A. Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis. Proc. Natl. Acad. Sci. U.S.A. 1990 Oct; 87(19):7653-7.

  146. Green R, Ellington AD, Szostak JW. In vitro genetic analysis of the Tetrahymena self-splicing intron. Nature 1990 Sep 27; 347(6291):406-8.

  147. Park EC, Szostak JW. Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. Mol. Cell. Biol. 1990 Sep; 10(9):4932-4.

  148. Ellington AD, Szostak JW. In vitro selection of RNA molecules that bind specific ligands. Nature 1990 Aug 30; 346(6287):818-22.

    149. 1989
  149. Doudna JA, Szostak JW. Miniribozymes, small derivatives of the sunY intron, are catalytically active. Mol. Cell. Biol. 1989 Dec; 9(12):5480-3.

  150. Michel F, Hanna M, Green R, Bartel DP, Szostak JW. The guanosine binding site of the Tetrahymena ribozyme. Nature 1989 Nov 23; 342(6248):391-5.

  151. Doudna JA, Cormack BP, Szostak JW. RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. Proc. Natl. Acad. Sci. U.S.A. 1989 Oct; 86(19):7402-6.

  152. Doudna JA, Szostak JW. RNA-catalysed synthesis of complementary-strand RNA. Nature 1989 Jun 15; 339(6225):519-22.

  153. Lundblad V, Szostak JW. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 1989 May 19; 57(4):633-43.

  154. Rajagopal J, Doudna JA, Szostak JW. Stereochemical course of catalysis by the Tetrahymena ribozyme. Science 1989 May 12; 244(4905):692-4.

  155. Nicolas A, Treco D, Schultes NP, Szostak JW. An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae. Nature 1989 Mar 2; 338(6210):35-9.

  156. Sun H, Treco D, Schultes NP, Szostak JW. Double-strand breaks at an initiation site for meiotic gene conversion. Nature 1989 Mar 2; 338(6210):87-90.

  157. Szostak JW. Telomerase: the beginning of the ends. Nature 1989 Jan 26; 337(6205):303-4.

    158. 1988
  158. Orr-Weaver TL, Nicolas A, Szostak JW. Gene conversion adjacent to regions of double-strand break repair. Mol. Cell. Biol. 1988 Dec; 8(12):5292-8.

  159. Murray AW, Claus TE, Szostak JW. Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae. Mol. Cell. Biol. 1988 Nov; 8(11):4642-50.

  160. Allshire RC, Gosden JR, Cross SH, Cranston G, Rout D, Sugawara N, Szostak JW, Fantes PA, Hastie ND. Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature 1988 Apr 14; 332(6165):656-9.

    161. 1987
  161. Matsumoto T, Fukui K, Niwa O, Sugawara N, Szostak JW, Yanagida M. Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe. Mol. Cell. Biol. 1987 Dec; 7(12):4424-30.

  162. Murray AW, Szostak JW. Artificial chromosomes. Sci. Am. 1987 Nov; 257(5):62-8.

  163. Reynolds AE, Murray AW, Szostak JW. Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae. Mol. Cell. Biol. 1987 Oct; 7(10):3566-73.

  164. Whiteway M, Freedman R, Van Arsdell S, Szostak JW, Thorner J. The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Mol. Cell. Biol. 1987 Oct; 7(10):3713-22.

  165. Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF. Structural conventions for group I introns. Nucleic Acids Res. 1987 Sep 25; 15(18):7217-21.

  166. Doudna JA, Gerber AS, Cherry JM, Szostak JW. Genetic dissection of an RNA enzyme. Cold Spring Harb. Symp. Quant. Biol. 1987; 52:173-80.

    167. 1986
  167. Dawson DS, Murray AW, Szostak JW. An alternative pathway for meiotic chromosome segregation in yeast. Science 1986 Nov 7; 234(4777):713-7.

  168. Murray AW, Szostak JW. Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae. Mol. Cell. Biol. 1986 Sep; 6(9):3166-72.

  169. Szostak JW. Enzymatic activity of the conserved core of a group I self-splicing intron. Nature ; 322(6074):83-6.

  170. Murray AW, Schultes NP, Szostak JW. Chromosome length controls mitotic chromosome segregation in yeast. Cell 1986 May 23; 45(4):529-36.

    171. 1985
  171. Whiteway M, Szostak JW. The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Cell 1985 Dec; 43(2 Pt 1):483-92.

  172. Orr-Weaver TL, Szostak JW. Fungal recombination. Microbiol. Rev. 1985 Mar; 49(1):33-58.

  173. Murray AW, Szostak JW. Chromosome segregation in mitosis and meiosis. Annu. Rev. Cell Biol. 1985; 1:289-315.

  174. Ruby SW, Szostak JW. Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Mol. Cell. Biol. 1985 Jan; 5(1):75-84.

    175. 1984
  175. Dunn B, Szauter P, Pardue ML, Szostak JW. Transfer of yeast telomeres to linear plasmids by recombination. Cell 1984 Nov; 39(1):191-201.

  176. Shampay J, Szostak JW, Blackburn EH. DNA sequences of telomeres maintained in yeast. Nature ; 310(5973):154-7.

    177. 1983
  177. Murray AW, Szostak JW. Pedigree analysis of plasmid segregation in yeast. Cell 1983 Oct; 34(3):961-70.

  178. Murray AW, Szostak JW. Construction of artificial chromosomes in yeast. Nature ; 305(5931):189-93.

  179. Sugawara N, Szostak JW. Recombination between sequences in nonhomologous positions. Proc. Natl. Acad. Sci. U.S.A. 1983 Sep; 80(18):5675-9.

  180. Orr-Weaver TL, Szostak JW. Yeast recombination: the association between double-strand gap repair and crossing-over. Proc. Natl. Acad. Sci. U.S.A. 1983 Jul; 80(14):4417-21.

  181. Szostak JW, Orr-Weaver TL, Rothstein RJ, Stahl FW. The double-strand-break repair model for recombination. Cell 1983 May; 33(1):25-35.

  182. Orr-Weaver TL, Szostak JW. Multiple, tandem plasmid integration in Saccharomyces cerevisiae. Mol. Cell. Biol. 1983 Apr; 3(4):747-9.

  183. Walmsley RM, Szostak JW, Petes TD. Is there left-handed DNA at the ends of yeast chromosomes? Nature 1983 Mar 3; 302(5903):84-6.

  184. Orr-Weaver TL, Szostak JW, Rothstein RJ. Genetic applications of yeast transformation with linear and gapped plasmids. Meth. Enzymol. 1983; 101:228-45.

  185. Szostak JW. A rapid procedure for the construction of linear yeast plasmids. Meth. Enzymol. 1983; 101:245-52.

  186. Ruby SW, Szostak JW, Murray AW. Cloning regulated yeast genes from a pool of lacZ fusions. Meth. Enzymol. 1983; 101:253-69.

  187. Sugawara N, Szostak JW. Construction of specific chromosomal rearrangements in yeast. Meth. Enzymol. 1983; 101:269-78.

  188. Brown PA, Szostak JW. Yeast vectors with negative selection. Meth. Enzymol. 1983; 101:278-90.

  189. Szostak JW. Replication and resolution of telomeres in yeast. Cold Spring Harb. Symp. Quant. Biol. 1983; 47 Pt 2:1187-94.

    190. 1982
  190. Szostak JW, Blackburn EH. Cloning yeast telomeres on linear plasmid vectors. Cell 1982 May; 29(1):245-55.

    191. 1981
  191. Orr-Weaver TL, Szostak JW, Rothstein RJ. Yeast transformation: a model system for the study of recombination. Proc. Natl. Acad. Sci. U.S.A. 1981 Oct; 78(10):6354-8.

  192. Stiles JI, Szostak JW, Young AT, Wu R, Consaul S, Sherman F. DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA. Cell 1981 Jul; 25(1):277-84.

    193. 1980
  193. Szostak JW, Wu R. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature 1980 Apr 3; 284(5755):426-30.

    194. 1979
  194. Szostak JW, Wu R. Insertion of a genetic marker into the ribosomal DNA of yeast. Plasmid 1979 Oct; 2(4):536-54.

  195. Szostak JW, Stiles JI, Tye BK, Chiu P, Sherman F, Wu R. Hybridization with synthetic oligonucleotides. Meth. Enzymol. 1979; 68:419-28.

    196. 1978
  196. Szostak J. [The system of measures and dosages in the 1st Polish herbaries]. Arch Hist Med (Warsz) 1978; 41(1):9-31.

    197. 1977
  197. Szostak JW, Stiles JI, Bahl CP, Wu R. Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA. Nature 1977 Jan 6; 265(5589):61-3.

  198. Szostak J. [Authors of the 1st Polish herbal: Stefan Falimirz, Hieronim Spiczy?ski, Marcin Siennik]. Arch Hist Med (Warsz) 1977; 40(3):277-89.

    199. 1976
  199. Szostak J. [Origins of Polish literature on medical pharmaceutics]. Arch Hist Med (Warsz) 1976; 39(4):389-404.

    200. 1972
  200. Benham S, Esping C, Masonhall W, Szostak J. Students' eye view of occupational health nursing. Occup Health Nurs 1972 Aug; 20(8):7-8.

Back to top