Blower Lab


Localization of specific RNAs to distinct subcellular destinations is an important posttranscriptional mechanism to control gene expression. During mitosis and meiosis cells remodel essentially every subcellular structure to ensure the proper segregation of chromosomes. We use a combination of cell biology, biochemistry, and bioinformatics to understand how cells orchestrate the remodeling of RNA localization during mitosis and meiosis and how this remodeling is coupled to changes in cellular structure and function.


RNA localization and Mitosis

FISH analysis demonstrating localization of the Xrhamm mRNA to microtubules during mitosis in a Xenopus tissue culture cell (from Sharp et al. 2011. MBoC).