Susana Garcia

Ruvkun Lab

Research Associate

Biotechnology Institute University of Helsinki


About Susana Garcia

I am interested in a group of toxic RNA species, containing nucleotide repeats in non-coding regions. Expansions of non-coding nucleotide repeats have been associated with a number degenerative disorders. My research focuses on the identification of pathways and mechanisms that regulate this RNA-dependent pathogenic process.

  1. Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G. Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature 2013 Jan 31; 493(7434):694-8.

  2. 2012
  3. Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification. Curr. Biol. 2012 May 22; 22(10):881-90.

  4. 2007
  5. Garcia SM, Casanueva MO, Silva MC, Amaral MD, Morimoto RI. Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells. Genes Dev. 2007 Nov 15; 21(22):3006-16.

  6. 2006
  7. Brignull HR, Morley JF, Garcia SM, Morimoto RI. Modeling polyglutamine pathogenesis in C. elegans. Meth. Enzymol. 2006; 412:256-82.

  8. 2004
  9. Nollen EA, Garcia SM, van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc. Natl. Acad. Sci. U.S.A. 2004 Apr 27; 101(17):6403-8.

  10. 2002
  11. Gerth C, Garcia SM, Ma L, Keltner JL, Werner JS. Multifocal electroretinogram: age-related changes for different luminance levels. Graefes Arch. Clin. Exp. Ophthalmol. 2002 Mar; 240(3):202-8.

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