Gabriel Hayes

Ruvkun Lab

Cell Biology

About Gabriel Hayes

Interests: microRNAs, development, classical music, gardening, tennis. I am interested in how microRNAs regulate the development of C. elegans. I have focused on how let-7 and its paralogs act together to direct the terminal differentiation of the stem-cell-like hypodermal seam cells and exit from the molting cycle. I am also elucidating how the transcriptional programs that direct these events are carried out.

  1. Hayes GD, Riedel CG, Ruvkun G. The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011 Oct 1; 25(19):2079-92.

  2. 2006
  3. Hayes GD, Frand AR, Ruvkun G. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development 2006 Dec; 133(23):4631-41.

  4. Hayes GD, Ruvkun G. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Cold Spring Harb. Symp. Quant. Biol. 2006; 71:21-7.

  5. 2004
  6. Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc. Natl. Acad. Sci. U.S.A. 2004 Jan 6; 101(1):360-5.

  7. 2003
  8. Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J. Computational and experimental identification of C. elegans microRNAs. Mol. Cell 2003 May; 11(5):1253-63.

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