Benjamin Heuberger

Szostak Lab

Research Fellow

About Benjamin Heuberger

In vitro RNA selection, synthetic chemistry, and nonenzymatic informational transfer.

  1. Heuberger BD, Pal A, Del Frate F, Topkar VV, Szostak JW. Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension. J. Am. Chem. Soc. 2015 Feb 25; 137(7):2769-75.

  2. 2014
  3. Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW. Crystal structure studies of RNA duplexes containing s(2)U:A and s(2)U:U base pairs. J. Am. Chem. Soc. 2014 Oct 1; 136(39):13916-24.

  4. 2012
  5. Kang M, Heuberger B, Chaput JC, Switzer C, Feigon J. Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4 T) in the presence of Cs+ ions. Angew. Chem. Int. Ed. Engl. 2012 Aug 6; 51(32):7952-5.

  6. 2009
  7. Nallagatla SR, Heuberger B, Haque A, Switzer C. Combinatorial synthesis of thrombin-binding aptamers containing iso-guanine. J Comb Chem ; 11(3):364-9.

  8. 2008
  9. Heuberger BD, Switzer C. An alternative nucleobase code: characterization of purine-purine DNA double helices bearing guanine-isoguanine and diaminopurine 7-deaza-xanthine base pairs. Chembiochem 2008 Nov 24; 9(17):2779-83.

  10. Heuberger BD, Shin D, Switzer C. Two Watson-Crick-like metallo base-pairs. Org. Lett. 2008 Mar 20; 10(6):1091-4.

  11. Heuberger BD, Switzer C. A pre-RNA candidate revisited: both enantiomers of flexible nucleoside triphosphates are DNA polymerase substrates. J. Am. Chem. Soc. 2008 Jan 16; 130(2):412-3.

  12. 2006
  13. Heuberger BD, Switzer C. Nonenzymatic oligomerization of RNA by TNA templates. Org. Lett. 2006 Dec 7; 8(25):5809-11.

  14. 2005
  15. Switzer C, Sinha S, Kim PH, Heuberger BD. A purine-like nickel(II) base pair for DNA. Angew. Chem. Int. Ed. Engl. 2005 Feb 25; 44(10):1529-32.

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