Sharmistha Kundu

Kingston Lab

Senior Scientist

Department of Molecular Biology
Simches Research Center
185 Cambridge Street, CPZN7250
Boston, MA 02114


About Sharmistha Kundu

My research goals include understanding how PRC1-mediated chromatin interactions change as pluripotent cells make specific cell-fate choices. To address this question, I am using neural differentiation of embryonic stem cells as a model. I completed my M.S. at the Indian Institute of Science, where I worked to develop a new in vitro system for studying transcription in a high DNA density environment. For my Ph.D. I worked with Craig Peterson at UMass Medical School, studying the role of chromatin remodeling during transcriptional choice in budding yeast. Prior to joining the Kingston lab, I was a JDRF fellow at Stanford University studying transcriptional regulation of pancreatic beta-cell formation and their proliferation during mouse embryonic development.

  1. Ardehali MB, Anselmo A, Cochrane JC, Kundu S, Sadreyev RI, Kingston RE. Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription. Mol. Cell 2017 Dec 07; 68(5):872-884.e6.

  2. Jaensch ES, Kundu S, Kingston RE. Multitasking by Polycomb response elements. Genes Dev. 2017 06 01; 31(11):1069-1072.

  3. Lau MS, Schwartz MG, Kundu S, Savol AJ, Wang PI, Marr SK, Grau DJ, Schorderet P, Sadreyev RI, Tabin CJ, Kingston RE. Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science 2017 03 10; 355(6329):1081-1084.

  4. Mueller B, Mieczkowski J, Kundu S, Wang P, Sadreyev R, Tolstorukov MY, Kingston RE. Widespread changes in nucleosome accessibility without changes in nucleosome occupancy during a rapid transcriptional induction. Genes Dev. 2017 03 01; 31(5):451-462.

  5. Kundu S, Ji F, Sunwoo H, Jain G, Lee JT, Sadreyev RI, Dekker J, Kingston RE. Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Mol. Cell 2017 Feb 02; 65(3):432-446.e5.

  6. 2016
  7. Deaton AM, Mieczkowski J, Tolstorukov MY, Kundu S, Sadreyev RI, Jansen LE, Kingston RE. Enhancer regions show high histone H3.3 turnover that changes during differentiation. Elife 2016 Jun 15; 5

  8. Mieczkowski J, Cook A, Bowman SK, Mueller B, Alver BH, Kundu S, Deaton AM, Urban JA, Larschan E, Park PJ, Kingston RE, Tolstorukov MY. MNase titration reveals differences between nucleosome occupancy and chromatin accessibility. Nat Commun 2016 May 06; 7:11485.

  9. 2013
  10. Zhou JX, Dhawan S, Fu H, Snyder E, Bottino R, Kundu S, Kim SK, Bhushan A. Combined modulation of polycomb and trithorax genes rejuvenates β cell replication. J. Clin. Invest. 2013 Nov; 123(11):4849-58.

  11. 2010
  12. Kundu S, Peterson CL. Dominant role for signal transduction in the transcriptional memory of yeast GAL genes. Mol. Cell. Biol. 2010 May; 30(10):2330-40.

  13. 2009
  14. Kundu S, Peterson CL. Role of chromatin states in transcriptional memory. Biochim. Biophys. Acta 2009 Jun; 1790(6):445-55.

  15. 2007
  16. Kundu S, Horn PJ, Peterson CL. SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster. Genes Dev. 2007 Apr 15; 21(8):997-1004.

  17. 2003
  18. Ghosh D, Faure N, Kundu S, Rondalez F, Chatterji D. Hybridization and Immobilization of Long ds-DNAs on Polystyrene Microspheres. Langmuir. 2003; 19(14):5830-5837.

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