Valentin Cracan

Mootha Lab

Assistant Professor

Scintillon Institute


  1. Titov DV, Cracan V, Goodman RP, Peng J, Grabarek Z, Mootha VK. Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science 2016 Apr 8; 352(6282):231-5.

  2. 2015
  3. Jost M, Born DA, Cracan V, Banerjee R, Drennan CL. Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases. J. Biol. Chem. 2015 Nov 6; 290(45):26882-98.

  4. Kitanishi K, Cracan V, Banerjee R. Engineered and Native Coenzyme B12-dependent Isovaleryl-CoA/Pivalyl-CoA Mutase. J. Biol. Chem. 2015 Aug 14; 290(33):20466-76.

  5. Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Cell Metab. 2015 Apr 7; 21(4):609-21.

  6. Jost M, Cracan V, Hubbard PA, Banerjee R, Drennan CL. Visualization of a radical B12 enzyme with its G-protein chaperone. Proc. Natl. Acad. Sci. U.S.A. 2015 Feb 24; 112(8):2419-24.

  7. 2014
  8. Hung V, Zou P, Rhee HW, Udeshi ND, Cracan V, Svinkina T, Carr SA, Mootha VK, Ting AY. Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging. Mol. Cell 2014 Jul 17; 55(2):332-41.

  9. 2013
  10. Gohil VM, Zhu L, Baker CD, Cracan V, Yaseen A, Jain M, Clish CB, Brookes PS, Bakovic M, Mootha VK. Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J. Biol. Chem. 2013 Dec 6; 288(49):35387-95.

  11. Cracan V, Banerjee R. Cobalt and corrinoid transport and biochemistry. Met Ions Life Sci 2013; 12:333-74.

  12. 2012
  13. Cracan V, Banerjee R. Novel B(12)-Dependent Acyl-CoA Mutases and Their Biotechnological Potential. 2012 Jul 23.

  14. Cracan V, Banerjee R. Novel coenzyme B12-dependent interconversion of isovaleryl-CoA and pivalyl-CoA. J. Biol. Chem. 2012 Feb 3; 287(6):3723-32.

  15. 2010
  16. Cracan V, Padovani D, Banerjee R. IcmF is a fusion between the radical B12 enzyme isobutyryl-CoA mutase and its G-protein chaperone. J. Biol. Chem. 2010 Jan 1; 285(1):655-66.

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