Tomohiko Kawate

Hung Lab

Seed Lab

Research Staff

Department of Molecular Biology
Simches Research Center
185 Cambridge Street, CPZN7250
Boston, MA 02114


About Tomohiko Kawate

I'm making compounds for discovery of anti-TB agents. I'm also working on new chemical probes for cell function.

  1. Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT. Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening. ACS Chem. Biol. 2012 Aug 17; 7(8):1377-84.

  2. Zhou L, Kawate T, Liu X, Kim YB, Zhao Y, Feng G, Banerji J, Nash H, Whitehurst C, Jindal S, Siddiqui A, Seed B, Wolfe JL. STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg. Med. Chem. 2012 Jan 15; 20(2):750-8.

  3. 2005
  4. Kawate T, Allerson CR, Wolfe JL. Regioselective syntheses of 7-nitro-7-deazapurine nucleosides and nucleotides for efficient PCR incorporation. Org. Lett. 2005 Sep 1; 7(18):3865-8.

  5. 2004
  6. Wolfe JL, Kawate T. Synthesis and polymerase incorporation of 5'-amino-2',5'-dideoxy-5'-N-triphosphate nucleotides. Curr Protoc Nucleic Acid Chem 2004 Oct; Chapter 13:Unit 13.3.

  7. 2003
  8. Wolfe JL, Wang BH, Kawate T, Stanton VP. Sequence-specific dinucleotide cleavage promoted by synergistic interactions between neighboring modified nucleotides in DNA. J. Am. Chem. Soc. 2003 Sep 3; 125(35):10500-1.

  9. 2002
  10. Wolfe JL, Kawate T, Belenky A, Stanton V. Synthesis and polymerase incorporation of 5'-amino-2',5'-dideoxy-5'-N-triphosphate nucleotides. Nucleic Acids Res. 2002 Sep 1; 30(17):3739-47.

  11. Wolfe JL, Kawate T, Sarracino DA, Zillmann M, Olson J, Stanton VP, Verdine GL. A genotyping strategy based on incorporation and cleavage of chemically modified nucleotides. Proc. Natl. Acad. Sci. U.S.A. 2002 Aug 20; 99(17):11073-8.

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