Natalia Kirienko

Ausubel Lab

Ruvkun Lab

Assistant Professor

Rice University


About Natalia Kirienko

I work in the Ausubel and Ruvkun labs, using C. elegans to study the conserved mechanisms of organismal defenses to stresses and infection with pathogens. In my spare time, I enjoy reading, hiking and swimming.

  1. Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature 2014 Sep 28.

  2. Kuzmanov A, Karina EI, Kirienko NV, Fay DS. The conserved PBAF nucleosome-remodeling complex mediates the response to stress in Caenorhabditis elegans. Mol. Cell. Biol. 2014 Mar; 34(6):1121-35.

  3. Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR. Pseudomonas aeruginosa PA14 pathogenesis in Caenorhabditis elegans. Methods Mol. Biol. 2014; 1149:653-69.

  4. Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV. High-throughput screening for novel anti-infectives using a C. elegans pathogenesis model. Curr Protoc Chem Biol 2014; 6(1):25-37.

  5. 2013
  6. Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat. Cell Biol. 2013 May; 15(5):491-501.

  7. Kirienko NV, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM. Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host Microbe 2013 Apr 17; 13(4):406-16.

  8. 2012
  9. Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM. Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection. PLoS Genet. 2012 Jun; 8(6):e1002733.

  10. McEwan DL, Kirienko NV, Ausubel FM. Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans. Cell Host Microbe 2012 Apr 19; 11(4):364-74.

  11. 2011
  12. Sait M, Kamneva OK, Fay DS, Kirienko NV, Polek J, Shirasu-Hiza MM, Ward NL. Genomic and Experimental Evidence Suggests that Verrucomicrobium spinosum Interacts with Eukaryotes. Front Microbiol 2011; 2:211.

  13. 2010
  14. Kirienko NV, Mani K, Fay DS. Cancer models in Caenorhabditis elegans. Dev. Dyn. 2010 May; 239(5):1413-48.

  15. Kirienko NV, Fay DS. SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network. EMBO J. 2010 Feb 17; 29(4):727-39.

  16. 2009
  17. Barends TR, Hartmann E, Griese JJ, Beitlich T, Kirienko NV, Ryjenkov DA, Reinstein J, Shoeman RL, Gomelsky M, Schlichting I. Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase. Nature 2009 Jun 18; 459(7249):1015-8.

  18. 2008
  19. Kirienko NV, McEnerney JD, Fay DS. Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and SLR-2. PLoS Genet. 2008 Apr; 4(4):e1000059.

  20. 2007
  21. Kirienko NV, Fay DS. Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental roles. Dev. Biol. 2007 May 15; 305(2):674-84.

  22. Bender AM, Kirienko NV, Olson SK, Esko JD, Fay DS. lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans. Dev. Biol. 2007 Feb 15; 302(2):448-62.

  23. 2004
  24. Kirienko NV, Lepikhov KA, Zheleznaya LA, Matvienko NI. Significance of codon usage and irregularities of rare codon distribution in genes for expression of BspLU11III methyltransferases. Biochemistry Mosc. 2004 May; 69(5):527-35.

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