Li Li

Szostak Lab

Research Fellow

Department of Molecular Biology
Simches Research Center
Boston, MA 02114


  1. Zhang W, Walton T, Li L, Szostak JW. Crystallographic observation of nonenzymatic RNA primer extension. Elife 2018 May 31; 7

  2. O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW. Copying of Mixed-Sequence RNA Templates inside Model Protocells. J. Am. Chem. Soc. 2018 04 18; 140(15):5171-5178.

  3. 2017
  4. Giurgiu C, Li L, O'Flaherty DK, Tam CP, Szostak JW. A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension. J. Am. Chem. Soc. 2017 11 22; 139(46):16741-16747.

  5. Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW. Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation. J. Am. Chem. Soc. 2017 07 05; 139(26):8780-8783.

  6. Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW. Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. J. Am. Chem. Soc. 2017 02 08; 139(5):1810-1813.

  7. 2016
  8. Li L, Lelyveld VS, Prywes N, Szostak JW. Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis. J. Am. Chem. Soc. 2016 Mar 30; 138(12):3986-9.

  9. 2015
  10. Izgu EC, Fahrenbach AC, Zhang N, Li L, Larsen AT, Blain JC, Szostak JW. Uncovering the thermodynamics of monomer binding for RNA replication. J. Am. Chem. Soc. 2015 May 20; 137(19):6373-82.

  11. 2014
  12. Sheng J, Li L, Engelhart AE, Gan J, Wang J, Szostak JW. Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proc. Natl. Acad. Sci. U.S.A. 2014 Feb 25; 111(8):3050-5.

  13. Li L, Szostak JW. The free energy landscape of pseudorotation in 3'-5' and 2'-5' linked nucleic acids. J. Am. Chem. Soc. 2014 Feb 19; 136(7):2858-65.

  14. 2013
  15. Li L, Martinis SA, Luthey-Schulten Z. Capture and quality control mechanisms for adenosine-5'-triphosphate binding. J. Am. Chem. Soc. 2013 Apr 24; 135(16):6047-55.

  16. Li L, Palencia A, Lukk T, Luthey-Schulten ZA, Cusack S, Martinis SA, Boniecki MT. Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens. Proc. Natl. Acad. Sci. U.S.A. 2013 Mar 05; 110(10):3817-22.

  17. 2011
  18. Li L, Boniecki MT, Jaffe JD, Imai BS, Yau PM, Luthey-Schulten ZA, Martinis SA. Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites. Proc. Natl. Acad. Sci. U.S.A. 2011 Jun 07; 108(23):9378-83.

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