Anand Minajigi

Lee Lab

Research Fellow

MGH Department of Medicine


About Anand Minajigi

I graduated from the Cell and Molecular Biology graduate program at the University of Vermont. I was engaged in deciphering the mechanism of aminoacylation and editing by aminoacyl-tRNA synthetases during protein synthesis under the guidance of Dr. Chris Francklyn. I joined the Lee group to explore the mechanism of Polycomb targeting in mammals.

  1. Minajigi A, Deng B, Francklyn CS. Fidelity escape by the unnatural amino acid ?-hydroxynorvaline: an efficient substrate for Escherichia coli threonyl-tRNA synthetase with toxic effects on growth. Biochemistry 2011 Feb 15; 50(6):1101-9.

  2. 2010
  3. Minajigi A, Francklyn CS. Aminoacyl transfer rate dictates choice of editing pathway in threonyl-tRNA synthetase. J. Biol. Chem. 2010 Jul 30; 285(31):23810-7.

  4. Francklyn CS, Minajigi A. tRNA as an active chemical scaffold for diverse chemical transformations. FEBS Lett. 2010 Jan 21; 584(2):366-75.

  5. 2008
  6. Minajigi A, Francklyn CS. RNA-assisted catalysis in a protein enzyme: The 2'-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase. Proc. Natl. Acad. Sci. U.S.A. 2008 Nov 18; 105(46):17748-53.

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