Rodrigo Aguilar Maureira

Lee Lab

Research Fellow


About Rodrigo Aguilar Maureira

I received my bachelor’s degree in Biochemistry from the Universidad de Concepcion and my Ph.D. in Molecular Biology at Universidad Andres Bello, both in Chile. My doctoral thesis under supervision of Dr. Martin Montecino was focused in epigenetic control of gene expression using differentiating stem cells and neuronal cells as models. Since I was especially attracted to understand gene repression, I joined to Dr. Lee’s Lab to study long non-coding RNAs in the context of X chromosome inactivation.

  1. Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, Härtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B.. Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice. Brain. 2017 Nov 16. doi: 10.1093/brain/awx272.

  2. Aguilar R*, Sepulveda H*, Prieto CP, Bustos F, Aedo S, Lattus J, van Zundert B, Palma V, Montecino M.. Epigenetic Signatures at the RUNX2-P1 and Sp7 Gene Promoters Control Osteogenic Lineage Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells. J Cell Physiol. 2017 Sep;232(9):2519-2527.

  3. 2016
  4. Aguilar R, Bustos FJ, Saez M, Rojas A, Allende ML, van Wijnen AJ, van Zundert B, Montecino M.. Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus. Biochim Biophys Acta. 2016 Aug;1859(8):1043-55.

  5. Lopez CI, Saud KE, Aguilar R, Berndt FA, Cánovas J, Montecino M, Kukuljan M.. The chromatin modifying complex CoREST/LSD1 negatively regulates Notch pathway during cerebral cortex development. Dev Neurobiol. 2016 Apr 25. doi: 10.1002/dneu.22397. Supplementary info.

  6. 2015
  7. Montecino M, Stein G, Stein J, Zaidi K, Aguilar R.. Multiple levels of epigenetic control for bone biology and pathology. Bone. 2015 Dec;81:733-8.

  8. Rojas A, Aguilar R, Henriquez B, Lian JB, Stein JL, Stein GS, van Wijnen AJ, van Zundert B, Allende ML, Montecino M. Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B. J Biol Chem. 2015 Nov 20;290(47):28329-42.

  9. Cánovas J, Berndt FA, Sepúlveda H, Aguilar R, Veloso FA, Montecino M, Oliva C, Maass JC, Sierralta J, Kukuljan M.. The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a. J Neurosci. 2015 May 13;35(19):7552-64.

  10. 2014
  11. Aguilar R, Grandy R, Meza D, Sepulveda H, Pihan P, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M.. A functional N-terminal domain in C/EBPbeta-LAP is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. J Cell Physiol. 2014 Oct;229(10):1521-8.

  12. 2013
  13. Henriquez B, Bustos FJ, Aguilar R, Becerra A, Simon F, Montecino M, van Zundert B.. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Mol Cell Neurosci. 2013 Nov;57:130-43.

  14. 2011
  15. Grandy R, Sepulveda H, Aguilar R, Pihan P, Henriquez B, Olate J, Montecino M.. The Ric-8B gene is highly expressed in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and C/EBPbeta-mediated manner. Mol Cell Biol. 2011 Jul;31(14):2997-3008.

  16. 2010
  17. Puchi M, García-Huidobro J, Cordova C, Aguilar R, Dufey E, Imschenetzky M, Bustos P, Morin V.. A new nuclear protease with cathepsin L properties is present in HeLa and Caco-2 cells. J Cell Biochem. 2010 Dec 1;111(5):1099-106.

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