Martin Newman

Ruvkun Lab

About Martin Newman

I am currently investigating how pre-mRNA splicing interacts with small regulatory RNA pathways to mediate silencing of foreign nucleic acid elements (such as trasposons and viruses) that can potentially damage the integrity of our genomes. I am also studying the functions of microRNAs in conferring resistance to bacterial pathogens.

  1. Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G. Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature 2013 Jan 31; 493(7434):694-8.

  2. 2011
  3. Newman MA, Mani V, Hammond SM. Deep sequencing of microRNA precursors reveals extensive 3' end modification. RNA 2011 Oct; 17(10):1795-803.

  4. 2010
  5. Newman MA, Hammond SM. Lin-28: an early embryonic sentinel that blocks Let-7 biogenesis. Int. J. Biochem. Cell Biol. 2010 Aug; 42(8):1330-3.

  6. Newman MA, Hammond SM. Emerging paradigms of regulated microRNA processing. Genes Dev. 2010 Jun 1; 24(11):1086-92.

  7. 2009
  8. Dangi-Garimella S, Yun J, Eves EM, Newman M, Erkeland SJ, Hammond SM, Minn AJ, Rosner MR. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 2009 Feb 18; 28(4):347-58.

  9. 2008
  10. Newman MA, Thomson JM, Hammond SM. Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 2008 Aug; 14(8):1539-49.

  11. 2006
  12. Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T, Hammond SM. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006 Aug 15; 20(16):2202-7.

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