Carolyn Phillips

Ruvkun Lab

Assistant Professor

University of Sothern California



About Carolyn Phillips

Interests: small RNAs, chromatin structure, germ-line organization. I am characterizing factors involved in transposon silencing and endogenous small RNA pathways in C. elegans using genetic, cytological, and biochemical methods.

  1. Phillips CM, Montgomery TA, Breen PC, Ruvkun G. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012 Jul 1; 26(13):1433-44.

  2. Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet. 2012 Apr; 8(4):e1002616.

  3. 2011
  4. Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2011 Jan 25; 108(4):1201-8.

  5. 2009
  6. Sato A, Isaac B, Phillips CM, Rillo R, Carlton PM, Wynne DJ, Kasad RA, Dernburg AF. Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis. Cell 2009 Nov 25; 139(5):907-19.

  7. Phillips CM, Meng X, Zhang L, Chretien JH, Urnov FD, Dernburg AF. Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans. Nat. Cell Biol. 2009 Aug; 11(8):934-42.

  8. Phillips CM, McDonald KL, Dernburg AF. Cytological analysis of meiosis in Caenorhabditis elegans. Methods Mol. Biol. 2009; 558:171-95.

  9. 2006
  10. Phillips CM, Dernburg AF. A family of zinc-finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegans. Dev. Cell 2006 Dec; 11(6):817-29.

  11. 2005
  12. MacQueen AJ, Phillips CM, Bhalla N, Weiser P, Villeneuve AM, Dernburg AF. Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans. Cell 2005 Dec 16; 123(6):1037-50.

  13. Phillips CM, Wong C, Bhalla N, Carlton PM, Weiser P, Meneely PM, Dernburg AF. HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis. Cell 2005 Dec 16; 123(6):1051-63.

  14. 2002
  15. Collins-Schramm HE, Phillips CM, Operario DJ, Lee JS, Weber JL, Hanson RL, Knowler WC, Cooper R, Li H, Seldin MF. Ethnic-difference markers for use in mapping by admixture linkage disequilibrium. Am. J. Hum. Genet. 2002 Mar; 70(3):737-50.

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