Buck Samuel

Ruvkun Lab

Assistant Professor

Baylor College of Medicine


About Buck Samuel

Interests: Influence of natural microbes on host metabolism and physiology. C. elegans, like us, encounters a broad range with microbes over its lifetime. To survive, C. elegans has adapted to be highly tuned to microbial cues that allow it discriminate friend from foe. I utilize lab-raised strains that have been domesticated on E. coli plus their wild cousins and naturally associated microbes to identify conserved host-microbial response pathways that influence C. elegans physiology and metabolism. Outside of the lab, I enjoy photography, hiking, softball, cooking, urban exploration and home renovation.

  1. Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, Hammer RE, Williams SC, Crowley J, Yanagisawa M, Gordon JI. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc. Natl. Acad. Sci. U.S.A. 2008 Oct 28; 105(43):16767-72.

  2. 2007
  3. Samuel BS, Hansen EE, Manchester JK, Coutinho PM, Henrissat B, Fulton R, Latreille P, Kim K, Wilson RK, Gordon JI. Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut. Proc. Natl. Acad. Sci. U.S.A. 2007 Jun 19; 104(25):10643-8.

  4. 2006
  5. Samuel BS, Gordon JI. A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism. Proc. Natl. Acad. Sci. U.S.A. 2006 Jun 27; 103(26):10011-6.

  6. Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE. Metagenomic analysis of the human distal gut microbiome. Science 2006 Jun 2; 312(5778):1355-9.

  7. 2004
  8. Rawls JF, Samuel BS, Gordon JI. Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Proc. Natl. Acad. Sci. U.S.A. 2004 Mar 30; 101(13):4596-601.

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