Chen-Ching Yuan

Mootha Lab

Research Fellow


  1. Yadav S, Yuan CC, Kazmierczak K, Liang J, Huang W, Takeuchi LM, Kanashiro-Takeuchi RM, Szczesna-Cordary D. Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM. J. Mol. Med. 2019 Jul; 97(7):1033-1047.

  2. Powers JD, Yuan CC, McCabe KJ, Murray JD, Childers MC, Flint GV, Moussavi-Harami F, Mohran S, Castillo R, Zuzek C, Ma W, Daggett V, McCulloch AD, Irving TC, Regnier M. Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin. Proc. Natl. Acad. Sci. U.S.A. 2019 Jun 04; 116(23):11502-11507.

  3. Kazmierczak K, Liang J, Yuan CC, Yadav S, Sitbon YH, Walz K, Ma W, Irving TC, Cheah JX, Gomes AV, Szczesna-Cordary D. Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. FASEB J. 2019 Mar; 33(3):3152-3166.

  4. 2018
  5. Yuan CC, Kazmierczak K, Liang J, Zhou Z, Yadav S, Gomes AV, Irving TC, Szczesna-Cordary D. Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified mice. Proc. Natl. Acad. Sci. U.S.A. 2018 03 06; 115(10):E2338-E2347.

  6. 2017
  7. Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes AV, Wang Y, Burghardt TP, Szczesna-Cordary D. Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice. Cardiovasc. Res. 2017 Aug 01; 113(10):1124-1136.

  8. 2015
  9. Yuan CC, Muthu P, Kazmierczak K, Liang J, Huang W, Irving TC, Kanashiro-Takeuchi RM, Hare JM, Szczesna-Cordary D. Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice. Proc. Natl. Acad. Sci. U.S.A. 2015 Jul 28; 112(30):E4138-46.

  10. Yuan CC, Ma W, Schemmel P, Cheng YS, Liu J, Tsaprailis G, Feldman S, Ayme Southgate A, Irving TC. Elastic proteins in the flight muscle of Manduca sexta. Arch. Biochem. Biophys. 2015 Feb 15; 568:16-27.

  11. 2011
  12. Lu HE, Tsai MS, Yang YC, Yuan CC, Wang TH, Lin XZ, Tseng CP, Hwang SM. Selection of alkaline phosphatase-positive induced pluripotent stem cells from human amniotic fluid-derived cells by feeder-free system. Exp. Cell Res. 2011 Aug 01; 317(13):1895-903.

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