Hongjae Sunwoo

Lee Lab

Senior Scientist

Intellia Therapeutics


About Hongjae Sunwoo

During my PhD study with Dr. David Spector at Cold Spring Harbor Lab, I became fascinated by long non-coding RNAs (ncRNA) and characterized Men epsilon/beta as structural elements of nuclear paraspeckles. For postdoctoral work, I am turning my attention to two of the most famous ncRNAs, Xist and Tsix of the X-inactivation pathway. Here in the Lee lab, I will study how these and other long ncRNAs are involved in epigenetic regulation.

  1. Mao YS, Sunwoo H, Zhang B, Spector DL. Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs. Nat. Cell Biol. 2011 Jan; 13(1):95-101.

  2. 2009
  3. Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 2009 Jul 1; 23(13):1494-504.

  4. Sunwoo H, Dinger ME, Wilusz JE, Amaral PP, Mattick JS, Spector DL. MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Res. 2009 Mar; 19(3):347-59.

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