Xiaoyun Wu

Ruvkun Lab

Research Scientist, Broad Institute

About Xiaoyun Wu

Interests: Soma-germline distinction and its connection with RNAi. In metazoans, soma and germline carry distinct functions. Recently, our lab showed that this distinction requires the worm homologue of the Retinoblastoma gene, lin-35. lin-35/Rb mutants misexpress germline-specific markers in the soma. These worms are also more efficient at RNAi and show abnormal RAS activation. I wish to use genetic as well as functional genomic methods to understand how Rb prevents soma from germlinizing, and whether there is any connection between germlinization, RNAi and RAS signaling.