Jee Young An

Lee Lab

Research Fellow

Institute for Basic Science


About Jee Young An

During my PhD studies, I worked on the physiological functions of the N-end rule pathway including transcriptional silencing by histone modification during meiosis. Then I joined Dr. Jeannie Lee's lab as a postdoctoral fellow to study more about the mechanisms of epigenetic regulation. My current research interests focus on identifying new regulators of silencing.

  1. An JY, Kim E, Zakrzewska A, Yoo YD, Jang JM, Han DH, Lee MJ, Seo JW, de Rooij DG, Kwon YT. UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells. PLoS ONE 2012; 7(5):e37414.

  2. 2010
  3. Song JJ, Szczepanski MJ, Kim SY, An JY, Kwon YT, Alcala MA, Bartlett DL, Lee YJ. c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance. Cell. Signal. 2010 Mar; 22(3):553-63.

  4. An JY, Kim EA, Jiang Y, Zakrzewska A, Lee MJ, Mook-Jung I, Zhang Y, Kwon YT. UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 2010 Feb 2; 107(5):1912-7.

  5. Yang F, Cheng Y, An JY, Kwon YT, Eckardt S, Leu NA, McLaughlin KJ, Wang PJ. The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis. PLoS ONE 2010; 5(11):e14017.

  6. 2009
  7. Jeong JH, An JY, Kwon YT, Rhee JG, Lee YJ. Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J. Cell. Biochem. 2009 Jan 1; 106(1):73-82.

  8. 2008
  9. Jeong JH, An JY, Kwon YT, Li LY, Lee YJ. Quercetin-induced ubiquitination and down-regulation of Her-2/neu. J. Cell. Biochem. 2008 Oct 1; 105(2):585-95.

  10. Lee MJ, Pal K, Tasaki T, Roy S, Jiang Y, An JY, Banerjee R, Kwon YT. Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. Proc. Natl. Acad. Sci. U.S.A. 2008 Jan 8; 105(1):100-5.

  11. 2007
  12. Song JJ, An JY, Kwon YT, Lee YJ. Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. J. Biol. Chem. 2007 Jan 5; 282(1):319-28.

  13. 2006
  14. An JY, Seo JW, Tasaki T, Lee MJ, Varshavsky A, Kwon YT. Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Proc. Natl. Acad. Sci. U.S.A. 2006 Apr 18; 103(16):6212-7.

  15. Ouyang Y, Kwon YT, An JY, Eller D, Tsai SC, Diaz-Perez S, Troke JJ, Teitell MA, Marahrens Y. Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair. Mutat. Res. 2006 Apr 11; 596(1-2):64-75.

  16. 2005
  17. Kim KM, Song JJ, An JY, Kwon YT, Lee YJ. Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J. Biol. Chem. 2005 Dec 9; 280(49):41047-56.

  18. Lee MJ, Tasaki T, Moroi K, An JY, Kimura S, Davydov IV, Kwon YT. RGS4 and RGS5 are in vivo substrates of the N-end rule pathway. Proc. Natl. Acad. Sci. U.S.A. 2005 Oct 18; 102(42):15030-5.

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