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Jen Sheen Professor
Department of Genetics |
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| We are probing plant life by developing simple and powerful tools and strategies to unravel plant signal transduction pathways extending from sensors/receptors to signaling cascades and target genes and proteins that are central to energy and metabolic homeostasis, innate immunity, stress adaptation, cell fate specification, plant shape and architecture determination. Our investigations are guided by our curiosity and the desire to promote the use of green plants as a versatile and fascinating model system for discovering fundamental principles in the regulatory networks of living organisms. |
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| HMS Course | Genetics 369 | Molecular Mechanisms of Plant Signal Transduction | ||
| Genetics 300 | Molecular mechanisms of plant signal transduction (Lectures & seminars) | |||
| Genetics 369 | Molecular mechanisms of plant signal
transduction (Rotation) |
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Selected Publications:Liu, K-H., Liu, M., Lin, Z., Wang, Z-F., Chen, B., Liu, C., Guo, A., Konishi, M., Yanagisawa, S., Wagner, G. and Sheen, J. 2022. NIN-like protein 7 transcription factor is a plant nitrate sensor. Science 377:1419-1425 PDF Supplementary Material Ye, R.Q., Wang, M., Du, H., Chhajed, S., Koh, J., Liu, K-H., Shin, J., Wu, Y., Shi, L., Xu, L., Chen, S., Zhang, Y. and Sheen, J. 2022. Glucose-driven TOR-FIE-PRC2 signaling controls plant development. Nature Published online: 14 September 2022.PDF Jiang, W., Bush, J. and Sheen J., 2021. A Versatile and Efficient Plant Protoplast Platform for Genome Editing by Cas9 RNPs Front. Genome Ed. 3:719190 PDF SUPP doi: 10.3389/fgeed.2021.719190 Li L., Liu K-h. and Sheen J., 2021. Dynamic Nutrient Signaling Networks in Plants Ann Rev Cell Dev Biol 37:341-67 PDF doi: 10.1146/annurev-cellbio-010521-015047 Epub 2021 Aug 5 PMID: 34351784 PMCID: PMC8497281 Liu, K.H., Diener, A., Lin, Z., Liu, C. and Sheen, J. 2020. Primary nitrate responses via calcium signaling and diverse protein phosphorylation. J.Exp.Bot 71:4428-4441 PDF PMID: 31985788 PCMID: PMC7382375 doi: 10.1093/jxb/eraa047 Ramon, M., Dang, TVT., Broeckx, T., Hulsmans, S., Crepin N., Sheen, J. and Rolland, R. 2019. Default activation and nuclear translocation of the plant cellular energy sensor SnRK1 regulate metabolic stress responses and development. Plant Cell 31:1614-1632. Epub 2019 May 13 PDF doi: 10.1105/tpc.18.00500 PMID: 31123051 Wu, Y., Shi, L., Li, L., Fu, L., Liu, Y., Xiong, Y., and Sheen, J. 2019. Integration of nutrient, energy, light and hormone signalling via TOR in plants. J.Exp.Bot. 70:2227-2238 PDF PMID: 30715492 Shi, L., Wu, Y. and Sheen, J. 2018. TOR signaling in plants: conservation and innovation. Development 145 dev160887 doi: 10.1242/dev.160887 PDF PMID: 30482859 PMCID: PMC6294885 Liu, K.H., Niu, Y., Konish, M., Wu, Y., Du, H., Chung, H.S., Li, L., Boudsocq, M., McCormack, M., Maekawa, S., Ishida, T., Zhang, C., Shokat, K., Yanagisawa, S., and Sheen, J. 2017. Discovery of nitrate-CPK-NLP signaling in central nutrient-growth networks. Nature 545:311-316 PDF Li L. and Sheen, J. 2016. Dynamic and diverse sugar signaling. Curr. Opin. Plant Biol. 33:116-125 PDF Cheng, Z., Li, J.F., Niu, Y., Zhang, X.C., Woody, O.Z., Xiong, Y., Djonovic, S., Millet, Y., Bush, J., McConkey, B.J., Sheen, J., and Ausubel, F.M. 2015. Pathogen-secreted proteases activate a novel plant immune pathway. Nature 521:213-216 PDF Xiong, Y. and Sheen, J. 2015. Novel links in the plant TOR signaling network. Curr. Opin. Plant Biol. 28:83-91 PDF Sheen, J. 2014. Master regulators in plant glucose signaling networks. J. Plant Biol. 57:67-79 PDF Xiong, Y. and Sheen, J. 2014. TOR signaling network in plant growth and metabolism. Plant Physiol. 164:499-512 PDF Xiong, Y., McCormack, M., Hall, Q., Xiang, C.B. and Sheen, J. 2013. Glucose-TOR signalling reprograms the transcriptome and activates meristems. Nature 496:181-186 PDF Cheng, C., Gao, X., Feng, B., Sheen, J., Shan, L and He, P. 2013. Differential temperature operation of plant immune responses. Nature Commun. 4:2530 doi: 10.1038/ncomms3530 PDF Gao, X., Chen, X., Lin W., Lu, D., Niu, Y., Li, L., Cheng, C., McCormack, M., Sheen, J., Shan, L. and He, P. 2013. Bifurcation of Arabidopsis NLR immune signaling via Ca2+-sensor protein kinases. PLOS Pathogens 9:e1003127 PDF Boudsocq, M. and Sheen, J. 2013. CDPKs in immune and stress signaling. Trends in Plant Science. 18:30-40 PDF Li, J.F., Chung, H.S., Niu, Y., Bush, J., McCormack, M. and Sheen, J. 2013. Comprehensive protein-based artificial microRNA screens for effective gene silencing in plants. Plant Cell 25:1507-1522 PDF Li, J.F., Norville, E.J., Aach, J., McCormack, M., Zhang, D., Bush, J., Church, G.M. and Sheen, J. 2013. Multiplex and homologous recombination�mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nature Biotechnology 31:688-691 PDF Hwang, I., Sheen, J. and M�ller, B. 2012. Cytokinin signaling networks. Annual Review of Plant Biology 63:353-380 PDF Lee, H., Chah, O.K., Plotnikov, J. and Sheen, J. 2012. Stem Cell Signaling in Immunity and Development. CSHL Symposium on Quantitative Biology. Online doi:10.1101/sqb.2012.77.014837 PDF Tena, G., Boudsocq, M. and Sheen, J. 2011. Protein kinase signaling networks in plant innate immunity. Curr. Opin. Plant Biol. 14:519-529 PDF
Lee, H., Chah, O.K. and Sheen, J. 2011. Stem-cell-triggered immunity through by CLV3p-FLS2 signaling. Nature 473:376-379 PDF SUPP Boudsocq, M., Willman, M., McCormack, M., Lee, H., Shan, L., He., P., Bush, J., Cheng, S.H., and Sheen, J. 2010. Differential innate immune signalling via Ca2+ sensor protein kinases. Nature 464:418-423 PDF SUPP Yoo, S.D., Cho, Y.H.,, and Sheen, J. 2009. Emerging connections in the ethylene-signaling network. Trends in Plant Science.14:270-279 PDF Shan, L., He, P., Li, J., Heese, A., Peck, S.C., N�rnberger, T., Martin, G.B. and Sheen, J. 2008. Bacterial Effectors Target the Common Signaling Partner BAK1 to Disrupt Multiple MAMP Receptor Signaling Complexes and Impede Plant Immunity. Cell Host & Microbe 4:17-27 PDF SUPP M�ller, B. and Sheen, J. 2008. Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis. Nature 453:1094-1097 PDF SUPP Yoo, S-D., Cho Y-H., Tena G., Xiong. Y. and Sheen, J. 2008. Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. Nature 451:789-795 PDF SUPP Shan, L., He, P.,and Sheen, J. 2007. Intercepting host MAPK signaling cascades by bacterial type III effectors. Cell Host & Microbe 1:167-174 PDF SUPP Baena-Gonz�lez, E., Rolland, F., Thevelein, J.M. and Sheen, J. 2007. A central integrator of transcription networks in plant stress and energy signalling. Nature 448:938-943 PDF SUPP Yoo, S.D., Cho, Y.H.and Sheen, J. 2007. Arabidopsis Mesophyll Protoplasts: A versatile cell system for transient gene expression analysis. Nature Protocols 2:1565-1575. PMID 17585298 PDF SUPP Cho, Y.-H., Yoo, S.-D., Sheen, J. 2006. Regulatory Functions of Nuclear Hexokinase1 Complex in Glucose Signaling. Cell 127:579-589 PDF SUPP. Rolland, F., Baena-Gonz�lez, E., and Sheen, J. 2006. Sugar Sensing and Signaling in Plants: Conserved and Novel Mechanisms. Annual Review of Plant Biology 57:676-709 PDF He, P., Shan, L., Lin, N.-C., Martin, G.B., Kemmerling, B., N�rnberger, T., and Sheen, J. 2006. Specific Bacterial Suppressors of MAMP Signaling Upstream of MAPKKK in Arabidopsis Innate Immunity. Cell 125:563-575 PDF SUPP. Yanagisawa, S., Yoo, S.-D.and Sheen, J. 2003. Differential regulation of EIN3 stability by glucose and ethylene signaling in plants. Nature 425:521-525 PDF SUPP. Moore, B., Zhou, L.,Rolland, F., Hall, Q., Cheng, W.-H., Liu, Y.-X., Hwang, I., Jones, T., and Sheen, J. 2003. Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal Signaling. Science 300:332-336 PDF SUPP. Asai, T., Tena, G., Plotnikova, J., Willmann, M., Chiu, W-L., Gomez-Gomez, L., Boller, T., Ausubel, F.M., and Sheen, J. 2002. MAP kinase signaling cascade in Arabidopsis innate immunity. Nature 415:977-983 PDF Hwang,I. and Sheen, J. 2001. Two-component circuitry in Arabidopsis cytokinin signal transduction. Nature 27:413(6854):383-9 PDF
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