Publications
Ardiel EL, Lauziere A, Xu S, Harvey BJ, Christensen RP, Nurrish S, Kaplan JM, Shroff H. Stereotyped behavioral maturation and rhythmic quiescence in C. elegans embryos. Elife. 2022 Aug 5;11:e76836.
Gao L, Zhao J, Ardiel E, Hall Q, Nurrish S, Shroff H, Kaplan JM. Shank promotes action potential repolarization by recruiting BK channels to calcium microdomains. Elife. 2022 Mar 10;11:e75140.
Ravi B, Zhao J, Chaudhry SI, Signorelli R, Bartole M, Kopchock RJ, Guijarro C, Kang L, Collins KM, Kaplan JM. Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans. Genetics. 2021 08 09; 218(4).
Piggott CA, Wu Z, Nurrish S, Xu S, Chisholm AD, Jin Y, Kaplan JM. Caenorhabditis elegans junctophilin has tissue-specific functions and regulates neurotransmission with extended-synaptotagmin. Genetics. 2021 Aug 9;218(4):iyab063.
Qian KY, Zeng WX, Hao Y, Zeng XT, Liu H, Li L, Chen L, Tian FM, Chang C, Hall Q, Song CX, Gao S, Hu Z, Li Q, Tong XJ, Kaplan JM.Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner. Elife. 2021 Mar 31;10:e67170.
Li L, Liu H, Hall Q, Wang W, Yu Y, Hu Z, Kaplan JM. A Hyperactive Form of unc-13 Enhances Ca2+ Sensitivity and Synaptic Vesicle Release Probability in C. elegans.Cell Rep. 2019 Sep 10;28(11):2979-2995.e4.
Liu H, Li L, Nedelcu D, Hall Q, Zhou L, Wang W, Yu Y, Hu Z.Kaplan JM. A Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans. Elife. 2019 Feb 25;8:e40585.
Zhao T, Hao Y, Kaplan JM. Axonal Mitochondria Modulate Neuropeptide Secretion Through the Hypoxic Stress Response in Caenorhabditis elegans.Genetics. 2018 Sep;210(1):275-285.
Hao Y, Yang W, Ren J, Hall Q, Zhang Y, Kaplan JM. Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide. Elife. 2018 Jul 17;7:e36833.
Tong XJ, López-Soto EJ, Li L, Liu H, Nedelcu D, Lipscombe D, Hu Z, Kaplan JM. Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calcium Channels. Neuron 2017 Jul 19; 95(2):326-340.e5.
Pym E, Sasidharan N, Thompson-Peer KL, Simon DJ, Anselmo A, Sadreyev R, Hall Q, Nurrish S, Kaplan JM. Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression. Elife. 2017 05 06; 6.
Chen D, Taylor KP, Hall Q Kaplan JM. The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion. Genetics 2016 Nov; 204(3):1151-1159.
Choi S, Taylor KP, Chatzigeorgiou M, Hu Z, Schafer WR, Kaplan JM. Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release.PLoS Genet. 2015 Jul; 11(7):e1005359.
Hu Z, Vashlishan-Murray AB, Kaplan JM. NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release. J. Neurosci. 2015 Jan 21; 35(3):1038-42.
Tong XJ, Hu Z, Liu Y, Anderson D, Kaplan JM. A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors. Elife 2015; 4:e09648.
Choi S, Chatzigeorgiou M, Taylor KP, Schafer WR, Kaplan JM. Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans. Neuron 2013 Jun 5; 78(5):869-80.
Hu Z, Tong XJ, Kaplan JM. UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans. Elife 2013; 2:e00967.
Hu Z, Hom S, Kudze T, Tong XJ, Choi S, Aramuni G, Zhang W, Kaplan JM. Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science 2012 Aug 24; 337(6097):980-4.
Thompson-Peer KL, Bai J, Hu Z, Kaplan JM. HBL-1 patterns synaptic remodeling in C. elegans. Neuron 2012 Feb 9; 73(3):453-65. Download PDF
Hao Y, Hu Z, Sieburth D, Kaplan JM. RIC-7 promotes neuropeptide secretion. PLoS Genet. 2012 Jan; 8(1):e1002464. Download PDF
Hu Z, Pym EC, Babu K, Vashlishan Murray AB, Kaplan JM. A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release. Neuron 2011 Jul 14; 71(1):92-102. Download PDF
Babu K, Hu Z, Chien SC, Garriga G, Kaplan JM. The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling. Neuron 2011 Jul 14; 71(1):103-16. Download PDF
Bai J, Hu Z, Dittman JS, Pym EC, Kaplan JM. Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis. Cell 2010 Oct 29; 143(3):430-41. Download PDF
Ch'ng Q, Sieburth D, Kaplan JM. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet. 2008 Nov; 4(11):e1000283. Download PDF
McEwen JM, Kaplan JM. UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin. Mol. Biol. Cell 2008 Sep; 19(9):3836-46. Download PDF
Dittman JS, Kaplan JM. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorha J. Neurosci. 2008 Jul 9; 28(28):7104-12. Download PDF
Chun DK, McEwen JM, Burbea M, Kaplan JM. UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans. Mol. Biol. Cell 2008 Jul; 19(7):2682-95. Download PDF
Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell 2008 May 30; 133(5):903-15. Download PDF
Vashlishan AB, Madison JM, Dybbs M, Bai J, Sieburth D, Ch'ng Q, Tavazoie M, Kaplan JM. An RNAi screen identifies genes that regulate GABA synapses. Neuron 2008 May 8; 58(3):346-61.
Juo P, Harbaugh T, Garriga G, Kaplan JM. CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans. Mol. Biol. Cell 2007 Oct; 18(10):3883-93. Download PDF
Sieburth D, Madison JM, Kaplan JM. PKC-1 regulates secretion of neuropeptides. Nat. Neurosci. 2007 Jan; 10(1):49-57.
McEwen JM, Madison JM, Dybbs M, Kaplan JM. Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13. Neuron 2006 Aug 3; 51(3):303-15.
Dittman JS, Kaplan JM. Factors regulating the abundance and localization of synaptobrevin in the plasma membrane. Proc. Natl. Acad. Sci. U.S.A. 2006 Jul 25; 103(30):11399-404. Download PDF
Madison JM, Nurrish S, Kaplan JM. UNC-13 interaction with syntaxin is required for synaptic transmission. Curr. Biol. 2005 Dec 20; 15(24):2236-42.
Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. Systematic analysis of genes required for synapse structure and function. Nature 2005 Jul 28; 436(7050):510-7.
Dybbs M, Ngai J, Kaplan JM. Using microarrays to facilitate positional cloning: identification of tomosyn as an inhibitor of neurosecretion. PLoS Genet. 2005 Jul; 1(1):6-16. Download PDF
Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science 2005 May 20; 308(5725):1164-7.
Dreier L, Burbea M, Kaplan JM. LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of Neuron 2005 Apr 7; 46(1):51-64.
Juo P, Kaplan JM. The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Curr. Biol. 2004 Nov 23; 14(22):2057-62.
Grunwald ME, Mellem JE, Strutz N, Maricq AV, Kaplan JM. Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade. Proc. Natl. Acad. Sci. U.S.A. 2004 Mar 2; 101(9):3190-5. Download PDF
Grunwald ME, Kaplan JM. Mutations in the ligand-binding and pore domains control exit of glutamate receptors from the endoplasmic reticulum in C. ele Neuropharmacology 2003 Nov; 45(6):768-76.
Jacob TC, Kaplan JM. The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions. J. Neurosci. 2003 Mar 15; 23(6):2122-30.
Burbea M, Dreier L, Dittman JS, Grunwald ME, Kaplan JM. Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Neuron 2002 Jul 3; 35(1):107-20.
Kass J, Jacob TC, Kim P, Kaplan JM. The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. J. Neurosci. 2001 Dec 1; 21(23):9265-72.
Rongo C, Kaplan JM. CaMKII regulates the density of central glutamatergic synapses in vivo. Nature 1999 Nov 11; 402(6758):195-9.
Lackner MR, Nurrish SJ, Kaplan JM. Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release. Neuron 1999 Oct; 24(2):335-46.
Nurrish S, Ségalat L, Kaplan JM. Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites. Neuron 1999 Sep; 24(1):231-42.
Hart AC, Kass J, Shapiro JE, Kaplan JM. Distinct signaling pathways mediate touch and osmosensory responses in a polymodal sensory neuron. J. Neurosci. 1999 Mar 15; 19(6):1952-8.
Rongo C, Whitfield CW, Rodal A, Kim SK, Kaplan JM. LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell 1998 Sep 18; 94(6):751-9.
Berger AJ, Hart AC, Kaplan JM. G alphas-induced neurodegeneration in Caenorhabditis elegans. J. Neurosci. 1998 Apr 15; 18(8):2871-80.
Elkes DA, Cardozo DL, Madison J, Kaplan JM. EGL-36 Shaw channels regulate C. elegans egg-laying muscle activity. Neuron 1997 Jul; 19(1):165-74.
Kaplan JM. Sensory signaling in Caenorhabditis elegans. Curr Opin Neurobiol. 1996 Aug; 6(4):494-9.
Elkes DA, Cardozo DL, Madison J, Kaplan JM. EGL-36 Shaw channels regulate C. elegans egg-laying muscle activity. Neuron 1997 Jul; 19(1):165-74.
Hart AC, Sims S, Kaplan JM. Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor. Nature 1995 Nov 2; 378(6552):82-5.
Ségalat L, Elkes DA, Kaplan JM. Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans. Science 1995 Mar 17; 267(5204):1648-51.
Kaplan JM, Horvitz HR. A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 1993 Mar 15; 90(6):2227-31. Download PDF