 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
|
2022 Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes Strom KS and Szostak JW Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides Todisco M and Szostak JW Template-Free Assembly of Functional RNAs by Loop-Closing Ligation Wu LF, Liu Z, Roberts SJ, Su M, Szostak JW, Sutherland JD. Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying Zhang SJ, Duzdevich D, Ding D, Szostak JW. Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides Radakovic A, DasGupta S, Wright TH, Aitken HRM, and Szostak JW Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates Ding D, Zhou L, Giurgiu C, Szostak JW. 2021 Structure-activity relationships in nonenzymatic template-directed RNA synthesis Constantin Giurgiu, Ziyuan Fang, Harry R M Aitken, Seohyun Chris Kim, Lydia Pazienza, Shriyaa Mittal, Jack W Szostak Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides Janicki MJ, Kufner CL, Todd ZR, Kim SC, O'Flaherty DK, Szostak JW, Šponer J, Góra RW, Sasselov DD, Szabla R Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension Duzdevich D, Carr CE, Ding D, Zhang SJ, Walton TS, Szostak JW. The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis Kim SC, O'Flaherty DK, Giurgiu C, Zhou L, Szostak JW. In search of the RNA world on Mars. Mojarro A, Jin L, Szostak JW, Head JW 3rd, Zuber MT. A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry Radakovic A, Wright TH, Lelyveld VS, Szostak JW. Shielding from UV Photodamage: Implications for Surficial Origins of Life Chemistry on the Early Earth Todd ZR, Szostak JW, and Sasselov DD The Virtual Circular Genome Model for Primordial RNA Replication Zhou L, Ding D, Szostak JW. Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization. Zhang W, Kim SC, Tam CP, Lelyveld VS, Bala S, Chaput JC, Szostak JW. 2020 Bulk Self-Assembly of Giant, Unilamellar Vesicles. Kindt JT, Szostak JW, Wang A. Solid-Phase Synthesis of Sequence-Defined Informational Oligomers Strom KR and Szostak JW. Nonenzymatic RNA-templated Synthesis of N3' → P5' Phosphoramidate DNA O'Flaherty DK, Zhou L, Szostak JW. Assembly of a ribozyme ligase from short oligomers by nonenzymatic ligation Zhou L, O'Flaherty DK, Szostak JW. Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying Zhang SJ, Duzdevich D, Szostak JW. Template-directed copying of RNA by non-enzymatic ligation. Zhou L, O'Flaherty DK, Szostak JW. Deep sequencing of non-enzymatic RNA primer extension. Duzdevich D, Carr CE, Szostak JW. Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions. Todd ZR, Fahrenbach AC, Ranjan S, Magnani CJ, Szostak JW, Sasselov DD. S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression Yildirim O, Izgu EC, Damie M, Chalei V, Ji F, Sadreyev R, Szostak JW, Kingston RE. Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase. Lelyveld VS, Zhang W, Szostak JW. In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole-activated substrates. Walton T, DasGupta S, Duzdevich D, Oh SS, Szostak JW. A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides and 2'-deoxynucleotides. Kim SC, Zhou L, Zhang W, O'Flaherty DK, Rondo-Brovetto V, Szostak JW. Large phenotypic enhancement of structured random RNA pools. Chizzolini F, Passalacqua LFM, Oumais M, Dingilian AI, Szostak JW, Lupták A.
2019 Non-enzymatic primer extension with strand displacement. Zhou L, Kim SC, Ho KH, O'Flaherty DK, Giurgiu C, Wright TH, Szostak JW. Lipid constituents of model protocell membranes Wang A. and Szostak JW. Prebiotically Plausible "Patching" of RNA Backbone Cleavage through a 3'-5' Pyrophosphate Linkage. Wright TH, Giurgiu C, Zhang W, Radakovic A, O'Flaherty DK, Zhou L, Szostak JW. DNA polymerase activity on synthetic N3'→P5' phosphoramidate DNA templates. Lelyveld VS, O'Flaherty DK, Zhou L, Izgu EC, Szostak JW. UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth. Todd ZR, Szabla R, Szostak JW, Sasselov DD. Template-Directed Nonenzymatic Primer Extension Using 2-Methylimidazole-Activated Morpholino Derivatives of Guanosine and Cytidine. Zhang W, Pal A, Ricardo A, Szostak JW. Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3'-NP-DNA up to 25 Nucleotides Long Inside Model Protocells. O'Flaherty DK, Zhou L, Szostak JW. The mechanism of nonenzymatic template copying with imidazole-activated nucleotides. Walton T, Zhang W, Li L, Tam CP, Szostak JW. Transfer of Sequence Information and Replication of Diimine Duplexes. Strom KR, Szostak JW, Prywes N. Template-directed catalysis of a multi-step reaction pathway for nonenzymatic RNA primer extension. Walton T, Pazienza L, Szostak JW. Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods Matsushita-Ishiodori Y, Hanczyc MM, Wang A, Szostak JW, Yomo T. Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity Wang A, Chan Miller C, Szostak JW 2018 Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA Kim SC, O'Flaherty DK, Zhou L, Lelyveld VS, Szostak JW . Catalysis of Template-directed Nonenzymatic RNA Copying by Iron (II) Jin L, Engelhart AE, Zhang W, Adamala KP, Szostak JW . Protocells and RNA Self-Replication Joyce GF and Szostak JW . Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation Lin S, Liu Q, Lelyveld V, Choe J, Szostak JW and Gregory R. A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying Giurgiu C, Wright TH, O'Flaherty DK, Szostak JW . Crystallographic observation of nonenzymatic RNA primer extension Zhang W, Walton T, Li L, Szostak JW . Copying of Mixed-Sequence RNA Templates inside Model Protocells O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW . Preparation, Purification, and Use of Fatty Acid-containing Liposomes Jin L, Engelhart AE, Adamala KP, Szostak JW . Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution Jin L, Kamat NP, Jena S, Szostak JW . Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide Zhang W, Tam CP, Zhou L, Oh SS, Wang J, Szostak JW . Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth Todd ZR, Fahrenbach AC, Manani CJ, Ranjan S, Björkbom A, Szostak JW, Sasselov DD .
Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension Tam CP, Zhou L, Fahrenbach AC, Zhang W, Walton T, Szostak JW. 2017 A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension Giurgiu C, Li L, O'Flaherty DK, Tam CP, Szostak JW. A kinetic model of nonenzymatic RNA polymerization by cytidine-5'-phosphoro-2-aminoimidazolide Walton T, Szostak JW. Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P. UV-light-driven prebiotic synthesis of iron‒sulfur clusters Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L, Szostak JW, Sasselov DD, Sutherland JD, Mansy SS.
Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW. Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW. Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides Stairs S, Nikmal A, Bučar DK, Zheng SL, Szostak JW, Powner MW. The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life Szostak JW. Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW.
Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW. 2016 Unusual Base-Pairing Interactions in Monomer-Template Complexes Zhang W, Tam CP, Wang J, Szostak JW. N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes Izgu EC, Björkbom A, Kamat NP, Lelyveld VS, Zhang W, Jia TZ, Szostak JW. Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW. Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak
JW. On the origin of life Szostak JW. A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension. Walton T, Szostak JW. Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides. Prywes N, Blain JC, Del Frate F, Szostak
JW. Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. Prywes N, Michaels YS, Pal A, Oh SS, Szostak
JW. A simple physical mechanism enables homeostasis in primitive cells. Engelhart AE, Adamala KP, Szostak JW. Collaboration between primitive cell membranes and soluble catalysts. Adamala KP, Engelhart AE, Szostak JW. Experimental and computational evidence for a loose transition state in phosphoroimidazolide hydrolysis. Li L, Lelyveld VS, Prywes N, Szostak JW. Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. Izgu EC, Oh SS, Szostak JW. 2015 Pinpointing RNA-protein cross-Links with site-specific stable isotope-labeled oligonucleotides. Lelyveld VS, Björkbom A, Ransey EM, Sliz P,
Szostak JW. Bidirectional direct sequencing of noncanonical RNA by two-dimensional analysis of mass chromatograms. Björkbom A,
Lelyveld VS, Zhang S, Zhang W, Tam CP, Blain JC, Szostak JW. Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization. Larsen AT,
Fahrenbach AC, Sheng J, Pian J, Szostak JW. Electrostatic localization of RNA to protocell membranes by cationic hydrophobic peptides. Kamat NP, Tobe S,
Hill IT, Szostak JW. Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations. Adamala K,
Engelhard AE, Kamat NP, Jin L, Szostak JW. Uncovering the thermodynamics of monomer binding for RNA replication. Izgu EC, Fahrenbach AC, Zhang N, Li L, Zhang W, Larsen
AT, Blain JC, Szostak, JW. Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension. Heuberger BD, Pal A, Del Frate F, Topkar VV, Szostak JW. Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension. Adamala K, Engelhart AE,
Szostak JW. 2014 Controlled growth of filamentous fatty acid vesicles under flow. Hentrich C, Szostak JW. Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions. Budin I, Prywes N, Zhang N, Szostak JW. Crystal structure studies of RNA duplexes containing s(2)U:A and s(2)U:U base pairs. Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak
JW. Progress toward synthetic cells. Blain JC, Szostak JW. Rapid RNA exchange in aqueous two-phase system and coacervate droplets. Jia TZ, Hentrich C, Szostak JW. Structural insights into the effects of 2'-5' linkages on the RNA duplex. Sheng J, Li L, Engelhart AE, Gan J, Wang J,
Szostak JW. The free energy landscape of pseudorotation in 3'-5' and 2'-5' linked nucleic acids. Li L, Szostak JW. Synthesis and nonenzymatic template-directed polymerization of 2'-amino-2'-deoxythreose nucleotides. Blain JC, Ricardo A, Szostak JW. 2013 Nonenzymatic template-directed RNA synthesis inside model protocells. Adamala K, Szostak JW. Preparation of fatty acid micelles. Zhu TF, Budin I, Szostak JW. Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder. Zhu TF, Budin I, Szostak JW. Preparation of fatty acid or phospholipid vesicles by thin-film rehydration. Zhu TF, Budin I, Szostak JW. mRNA display: from basic principles to macrocycle drug discovery. Josephson K, Ricardo A, Szostak JW. Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer. Zhang S, Blain JC, Zielinska D, Gryaznov SM, Szostak JW. Proc Natl Acad Sci USA. 2013 Oct PDF. Competition between model protocells driven by an encapsulated catalyst. Adamala K, Szostak JW. Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity. Engelhart AE, Powner MW, Szostak JW. Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension. Zhang S, Zhang N, Blain JC, Szostak JW. 2012 Concentration-driven growth of model protocell membranes. Budin I, Debnath A, Szostak JW. Multicomponent assembly of proposed DNA precursors in water. Powner MW, Zheng SL, Szostak JW. The eightfold path to non-enzymatic RNA replication. Szostak JW. Photochemically driven redox chemistry induces protocell membrane pearling and division. Zhu TF, Adamala K, Zhang N, Szostak JW. In vitro selection of functional lantipeptides. Hofmann FT, Szostak JW, Seebeck FP. In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors. Guillen Schlippe YV, Hartman MC, Josephson K,
Szostak JW. Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template. Zhang N, Zhang S, Szostak JW. Attempts to define life do not help to understand the origin of life. Szostak JW. 2011 An optimal degree of physical and chemical heterogeneity for the origin of life? Szostak JW. Artificial lantipeptides from in vitro translations. Seebeck FP, Ricardo A, Szostak JW. Exploding vesicles. Zhu TF, Szostak JW. Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity. Trevino SG, Zhang N, Elenko MP, Luptak A, Szostak
JW. Physical effects underlying the transition from primitive to modern cell membranes. Budin I, Szostak JW. Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in vitro translation. Subtelny AO, Hartman MCT, Szostak JW. 2010 Chemoselective multicomponent one-pot assembly of purine precursors in water. Powner MW, Sutherland JD, Szostak JW. Single-molecule binding experiments on long time scales. Rev Sci Instrum. Elenko MP, Szostak JW, van Oijen AM. The origins of cellular life. Schrum JS, Zhu TF, Szostak JW. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak
MA, Szostak JW, Chen IA. Expanding roles for diverse physical phenomena during the origin of life. Budin I, Szostak JW. 2009 Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L,
Szostak JW. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers. Schrum JP, Ricardo A, Krishnamurthy M, Blain JC,
Szostak JW. Reconstructing the emergence of cellular life through the synthesis of model protocells. Mansy SS, Szostak JW. Origin of life on earth. Ricardo A, Szostak JW. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy. Lin S, Horning DP, Szostak JW, Chaput JC. Formation of protocell-like vesicles in a thermal diffusion column. Budin I, Bruckner RJ, Szostak JW. Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics. Elenko MP, Szostak JW, van Oijen AM. Origins of life: Systems chemistry on early Earth. Szostak JW. Preparation of large monodisperse vesicles. Zhu TF, Szostak JW. Coupled growth and division of model protocell membranes. Zhu TF, Szostak JW. Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. Chen JJ, Tsai CH, Cai X, Horhota AT, McLaughlin
LW, Szostak JW. N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system. Chen JJ, Cai X, Szostak JW. 2008 Thermostability of model protocell membranes. Mansy SS, Szostak JW. Template-directed synthesis of a genetic polymer in a model protocell. Mansy SS, Schrum JP, Krishnamurthy M, Tobé S,
Treco DA, Szostak JW. Ribosomal synthesis of N-methyl peptides. Subtelny AO, Hartman MC, Szostak JW. Metal-ion catalyzed polymerization in the eutectic phase in water-ice: A possible approach to template-directed RNA polymerization. Monnard PA, Szostak JW. 2007 An expanded set of amino Acid analogs for the ribosomal translation of unnatural peptides. Hartman MC, Josephson K, Lin CW, Szostak JW. Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template. Tsai CH, Chen J, Szostak JW. Selection and evolution of enzymes from a partially randomized non-catalytic scaffold. Seelig B, Szostak JW. Structure and evolutionary analysis of a non-biological ATP-binding protein. Mansy SS, Zhang J, Kummerle R, Nilsson M, Chou
JJ, Szostak JW, Chaput JC. Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW,
Chaput JC. Functional information and the emergence of biocomplexity. Hazen RM, Griffin PL, Carothers JM, Szostak JW. 2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. Meena, Sam M, Pierce K, Szostak JW, McLaughlin LW. 2006 Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities. Horhota AT, Szostak JW, McLaughlin LW. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Blackburn EH, Greider CW, Szostak JW. A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene. Salehi-Ashtiani K, Luptak A, Litovchick A, Szostak JW.
Mineral surface directed membrane assembly. Hanczyc MM, Mansy SS, Szostak JW. Aptamers selected for higher-affinity binding are not more
specific for the target ligand. Carothers JM, Oestreich SC, Szostak JW. Ribosomal synthesis of dehydroalanine-containing peptides. Seebeck FP, Szostak JW. Enzymatic aminoacylation of tRNA with unnatural amino acids. Hartman MC, Josephson K, Szostak JW. Proc Natl Acad Sci U S A. 2006 Mar. PDF Supporting Information Solution structure of an informationally complex high-affinity RNA aptamer to GTP. Carothers JM, Davis JH, Chou JJ, Szostak
JW. Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display. Cho GS, Szostak JW. 2005 Shrink-wrap vesicles. Fujikawa SM, Chen IA, Szostak JW. In vitro selection of RNA aptamers against a composite small molecule-protein surface. Plummer KA, Carothers JM, Yoshimura M, Szostak JW,
Verdine GL. RNA catalysis in model protocell vesicles. Chen IA, Salehi-Ashtiani K, Szostak JW. High fidelity TNA synthesis by Therminator polymerase. Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak
JW. Ribosomal synthesis of unnatural peptides. Josephson K, Hartman MC, Szostak JW. Kinetic analysis of an efficient DNA-dependent TNA polymerase. Horhota A, Zou K, Ichida JK, Yu B, McLaughlin
LW, Szostak JW, Chaput JC. Scanning the human proteome for calmodulin-binding proteins. Shen X, Valencia CA, Szostak JW, Dong B, Liu R. Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose. Sacerdote MG, Szostak JW. Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs). Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW. An in vitro selection system for TNA. Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak
JW. 2004 Replicating vesicles as models of primitive cell growth and division. Hanczyc MM, Szostak JW. The emergence of competition between model protocells. Chen, IA, Roberts, RW, Szostak, JW. A kinetic study of the growth of fatty acid vesicles. Chen IA, Szostak JW. A small aptamer with strong and specific recognition of the triphosphate of ATP. Sazani PL, Larralde R, Szostak JW. Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability. Chaput JC, Szostak JW. Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles. Chen IA, Szostak JW. Informational complexity and functional activity of RNA structures. Carothers JM, Oestreich SC, Davis JH, Szostak JW. 2003 Experimental models of primitive cellular compartments: encapsulation, growth, and division. Hanczyc, MM, Fujikawa, SM, Szostak, JW. TNA synthesis by DNA polymerases. Chaput, JC, Szostak, JW. A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality. Vaish, NK, Larralde, R. Fraley, AW, Szostak, JW,
McLaughlin, LW. Functional information: molecular messages. Szostak, JW. Selective labeling and detection of specific RNAs in an RNA mixture. Huang, Z, and Szostak, JW. DNA polymerase-mediated DNA synthesis on a TNA template. Chaput, JC, Ichida, JK, Szostak, JW. 2002 Isolation of high-affinity GTP aptamers from partially structured RNA libraries. Davis, JH, Szostak, JW. Identification of epitope-like consensus motifs using mRNA display. Burgstaller P, Hale S, Sun L, Roberts RW,
Szostak JW, Wagner R. 2001 In vitro evolution suggests multiple origins for the hammerhead ribozyme. Salehi-Ashtiani K, Szostak JW. Synthesizing Life. Szostak JW, Bartel, DP and Luisi, PL. Functional proteins from a random-sequence library. Keefe AD, Szostak JW. One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. Keefe AD, Wilson, DS, Seelig, B, and Szostak JW. The use of mRNA display to select high-affinity protein-binding peptides. Wilson DS, Keefe AD, Szostak JW. 2000 Constructing high complexity synthetic libraries of long ORFs using in vitro selection. Cho, G, Keefe, AD, Wilson, DS, Liu, R and
Szostak, JW. Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. Vaish NK, Fraley AW, Szostak JW, McLaughlin
LW. Ribozyme-catalyzed tRNA aminoacylation. Lee N, Bessho Y, Wei K, Szostak JW, Suga
H. Optimized synthesis of RNA-protein fusions for in vitro protein selection. Liu R, Barrick JE, Szostak JW, Roberts RW. Methods Enzymol. 2000;318:268-93. 1999 In vitro Selection of functional nucleic acids. Wilson DW, Szostak JW. 1998 In vitro selection and directed evolution. Szostak JW. Isolation and characterization of fluorophore-binding RNA aptamers. Holeman LA, Robinson SL, Szostak JW and Wilson
C. Folding & Isolation of a fluorophore-specific DNA aptamer with weak redox activity. Wilson C, Szostak JW. Functional requirements for specific ligand recognition by a biotin-binding RNA pseudoknot. Wilson C, Nix J, Szostak JW. Unusual metal ion catalysis in an acyl transferase ribozyme. Suga H, Cowan JA, Szostak JW. Structural and kinetic characterization of an acyl transferase ribozyme. Suga H, Lohse P, Szostak JW. 1997 RNA-peptide fusions for the in Vitro selection of peptides and proteins. Roberts RW, Szostak JW. Isolation of novel ribozymes that ligate AMP-activated RNA substrates. Hager AJ, Szostak JW. Mutant ATP-Binding RNA aptamers reveal the structural basis for ligand binding. Dieckmann T, Butcher SE, Sassanfar M, Szostak
JW and Feigon J. Introduction: Combinatorial Chemistry. Szostak JW. 1996 Ribozymes: aiming at RNA replication and translation. Hager AJ, Pollard JD, Szostak JW. 3' End-Labeling of RNA with DNA Polymerase. Huang Z, Szostak JW. Ribozyme-catalysed amino acid transfer reactions. Lohse P, Szostak JW. Non-enzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. Rohatgi R, Bartel D, Szostak JW. Kinetic and mechanistic analysis of nonenzymatic, template-directed oligonucleotide ligation. Rohatgi R, Bartel D, Szostak JW. Chance and necessity in the selection of nucleic acid catalysts. Lorsch JR, Szostak JW. In vitro selection of nucleic acid sequences that bind small molecules. Lorsch JR, Szostak JW. 1995 Reverse transcriptase reads through a 2'-5' linkage and a 2'-thiophosphate in a template. Lorsch JR, Bartel DP, Szostak JW. Structurally complex and highly active RNA ligases derived from random RNA sequences. Ekland EH, Szostak JW, Bartel DP. A DNA metalloenzyme with DNA ligase activity. Cuenod B, Szostak JW. Isolation of a ribozyme with 5'-5' ligase activity. Chapman KB, Szostak JW. In vitro evolution of a self-alkylating ribozyme. Wilson CW, Szostak JW. Total chemical synthesis of a ribozyme derived from a group I intron. Whoriskey S, Usman N, Szostak JW. RNA aptamers that bind flavin and nicotinamide redox cofactors. Lauhon CT, Szostak JW. DNA aptamer that binds adenosine and ATP. Huizenga DE, Szostak JW. 1994 Study of RNA-protein recognition by in vitro selection. Bartel DP, Szostak JW. Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. Hanna M, Szostak JW. In vitro evolution of new ribozymes with polynucleotide kinase activity. Lorsch JR, Szostak JW. In vitro selection of catalytic RNAs. Chapman KB, Szostak JW. Template-directed oligonucleotide assembly reactions catalyzed by a minimally structured ribozyme derived from a group I intron. Green R, Szostak JW. NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element. Peterson RD, Bartel DP, Szostak JW, Horvath SJ,
Feigon J. In vitro selection of RNA aptamers specific for cyanocobalamin. Lorsch J, Szostak, JW. Evidence that the guanosine substrate of the tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding. Lin, C-W, Szostak JW. In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. Green R, Szostak JW. 1993 Isolation of a new ribozymes from a large pool of random sequences. Bartel DP, Szostak JW. An RNA motif that binds ATP. Sassanfar M, Szostak JW. Selection of functional RNA and DNA molecules from randomized sequences. Famulok M, Szostak JW. In vitro selection of functional RNA sequences. Szostak, J.W. and Ellington, A.E. Triplet extension: a novel strategy for RNA catalysed RNA replication. Doudna JA, Szostak JW. 1992 Selection of a ribozyme that functions as a superior template in a self-copying reaction. Green R and Szostak JW. Ribozyme catalysis. Wilson CL, Szostak JW. In vitro selection of specific ligand binding nucleic acids. Famulok M, Szostak JW. Stereospecific recognition of tryptophan agarose by in vitro selected RNA. Famulok M, Szostak JW. In vitro genetics. Szostak JW. Selection in vitro of single-stranded DNA molecules that fold into specific ligand binding structures. Ellington AE, Szostak JW. 1991 Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice-site of the Tetrahymena group I intron. Green R, Szostak JW, Benner SA, Rich A, Usman
N. HIV-1 Rev regulation involves recognition of non-Watson-Crick base-pairs in viral RNA. Bartel DP, Zapp M, Green M, Szostak JW. In vitro genetic analysis: selection and amplification of rare functional nucleic acids. Green R, Ellington AD, Bartel DP, Szostak
JW. Template-directed primer extension catalyzed by the Tetrahymena ribozyme. Bartel DP, Szostak JW. A multi-subunit ribozyme that is a catalyst of and a template for complementary strand RNA synthesis. Doudna JA, Couture S, Szostak JW. 1990 Chemical synthesis of oligoribonucleotides containing 2-aminopurine: Substrates for the investigation of ribozyme function. Doudna JA, Szostak JW, Rich A, Usman N. Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns. Couture S, Ellington AD, Gerber AS, Cherry JM,
Doudna JA, Green R, Hanna M, Pace U, Rajogopal J, Szostak
JW. In vitro selection of RNA molecules that bind specific ligands. Ellington AE, Szostak JW. 1989 Miniribozymes, small derivatives of the sunY intron, are catalytically active. Michel F, Hanna M, Green R, Bartel DB, Szostak
JW. Stereochemical course of catalysis by the Tetrahymena ribozyme. Rajagopal J, Doudna JA, Szostak JW. 1987 Genetic dissection of an RNA enzyme. Doudna JA, Cormack BP, Szostak JW. |
||
| || | research | || | people | || | publications | || | movies | || | resources | || | join | || |
© 2016 Szostak Lab |